Anti-Recombinant-FPGS antibody (450-587) [S4141RM] (STJ11104141)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal Recombinant-Folylpolyglutamate Synthase-Mitochondrial (450-587) antibody for use in WB and ELISA in human and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | S4141RM |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:100-1:500ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | FPGS |
| Gene ID | 2356 |
| Uniprot ID | FOLC_HUMAN |
| Immunogen Region | 450-587 |
| Immunogen Sequence | NADQQNFTVTLDQVLLRCLE HQQHWNHLDEEQASPDLWSA PSPEPGGSASLLLAPHPPHT CSASSLVFSCISHALQWISQ GRDPIFQPPSPPKGLLTHPV AHSGASILREAAAIHVLVTG SLHLVGGVLKLLEPALSQ |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 450-587 of human FPGS (Q05932). |
Additional Info
| Function | Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis. Unsubstituted reduced folates are the preferred substrates. Metabolizes methotrexate (MTX) to polyglutamates. |
| Protein Name | Folylpolyglutamate Synthase - MitochondrialFolylpoly-Gamma-Glutamate SynthetaseFpgsTetrahydrofolylpolyglutamate SynthaseTetrahydrofolate Synthase |
| Database Links | Reactome: R-HSA-196757 |
| Cellular Localisation | Isoform 1: Mitochondrion Inner MembraneMitochondrion MatrixIsoform 2: Cytoplasm |
| Alternative Antibody Names | Anti-Folylpolyglutamate Synthase - Mitochondrial antibodyAnti-Folylpoly-Gamma-Glutamate Synthetase antibodyAnti-Fpgs antibodyAnti-Tetrahydrofolylpolyglutamate Synthase antibodyAnti-Tetrahydrofolate Synthase antibodyAnti-FPGS antibody |
Information sourced from Uniprot.org