Anti-Recombinant-FKTN antibody [RM1E98] (STJA0023092)

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STJA0023092
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Short Description :Rabbit monoclonal anti-Recombinant-Ribitol-5-Phosphate Transferase Fktn for use in IHC and WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents.
Applications:IHC/WB
Host:Rabbit
Reactivity:Human/Mouse/Rat
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality :Monoclonal
Clone ID :RM1E98
Isotype:IgG
Conjugation:Unconjugated
Purification:Protein A/G purified from cell culture supernatant
Dilution Range:IHC: 1:100-1:200
Formulation:0.01M PBS
Storage Instruction:Suitable for storage at +4°C between 1-2 weeks. For longer term store at-20°C for up to 12 months.
Gene Symbol:FKTN
Gene ID:2218
Uniprot ID:FKTN_HUMAN
Function Catalyzes the transfer of a ribitol-phosphate from CDP-ribitol to the distal N-acetylgalactosamine of the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N-acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan (DAG1). This constitutes the first step in the formation of the ribitol 5-phosphate tandem repeat which links the phosphorylated O-mannosyl trisaccharide to the ligand binding moiety composed of repeats of 3-xylosyl-alpha-1,3-glucuronic acid-beta-1. Required for normal location of POMGNT1 in Golgi membranes, and for normal POMGNT1 activity. May interact with and reinforce a large complex encompassing the outside and inside of muscle membranes. Could be involved in brain development (Probable).
Protein Name Ribitol-5-Phosphate Transferase Fktn
Fukutin
Fukuyama-Type Congenital Muscular Dystrophy Protein
Ribitol-5-Phosphate Transferase
Database Links
Cellular Localisation Golgi Apparatus Membrane
Single-Pass Type Ii Membrane Protein
Cytoplasm
Nucleus
In Retinal Tissue
Does Not Localize With The Golgi Apparatus
Alternative Antibody Names Anti-Ribitol-5-Phosphate Transferase Fktn antibody
Anti-Fukutin antibody
Anti-Fukuyama-Type Congenital Muscular Dystrophy Protein antibody
Anti-Ribitol-5-Phosphate Transferase antibody
Anti-FKTN antibody
Anti-FCMD antibody

Information sourced from Uniprot.org

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