Anti-Recombinant-ERLIN2 antibody [RM1G09] (STJA0023201)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal anti-Recombinant-Erlin-2 for use in IF, IHC and WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IF/IHC/WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | RM1G09 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Protein A/G purified from cell culture supernatant |
| Dilution Range | IF: 1:50-1:200 |
| Formulation | 0.01M PBS |
| Storage Instruction | Suitable for storage at +4°C between 1-2 weeks. For longer term store at-20°C for up to 12 months. |
Target Information
| Gene Symbol | ERLIN2 |
| Gene ID | 11160 |
| Uniprot ID | ERLN2_HUMAN |
Additional Info
| Post Translational Modifications | Deubiquitinated by USP25.leading to stabilization. |
| Function | Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs) such as ITPR1. Promotes sterol-accelerated ERAD of HMGCR probably implicating an AMFR/gp78-containing ubiquitin ligase complex. Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. May promote ER retention of the SCAP-SREBF complex. |
| Protein Name | Erlin-2Endoplasmic Reticulum Lipid Raft-Associated Protein 2Stomatin-Prohibitin-Flotillin-Hflc/K Domain-Containing Protein 2Spfh Domain-Containing Protein 2 |
| Database Links | Reactome: R-HSA-382556Reactome: R-HSA-5655302Reactome: R-HSA-5678895Reactome: R-HSA-8853336 |
| Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Type Ii Membrane ProteinAssociated With Lipid Raft-Like Domains Of The Endoplasmic Reticulum Membrane |
| Alternative Antibody Names | Anti-Erlin-2 antibodyAnti-Endoplasmic Reticulum Lipid Raft-Associated Protein 2 antibodyAnti-Stomatin-Prohibitin-Flotillin-Hflc/K Domain-Containing Protein 2 antibodyAnti-Spfh Domain-Containing Protein 2 antibodyAnti-ERLIN2 antibodyAnti-C8orf2 antibodyAnti-SPFH2 antibodyAnti-UNQ2441 antibodyAnti-PRO5003 antibodyAnti-PRO9924 antibody |
Information sourced from Uniprot.org