Anti-Recombinant-EPS15L1/EPS15R antibody [RM2S45] (STJA0026603)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal anti-Recombinant-Epidermal Growth Factor Receptor Substrate 15-Like 1 for use in IP and WB in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IP/WB |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | RM2S45 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Protein A/G purified from cell culture supernatant |
| Dilution Range | IP: 1:20, WB: 1:500-1:1000 |
| Formulation | 0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium Azide |
| Storage Instruction | Suitable for storage at +4°C between 1-2 weeks. For longer term store at-20°C for up to 12 months. |
Target Information
| Gene Symbol | EPS15L1 |
| Gene ID | 58513 |
| Uniprot ID | EP15R_HUMAN |
Additional Info
| Function | Seems to be a constitutive component of clathrin-coated pits that is required for receptor-mediated endocytosis. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR).internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2. |
| Protein Name | Epidermal Growth Factor Receptor Substrate 15-Like 1Eps15-Related ProteinEps15r |
| Database Links | Reactome: R-HSA-182971Reactome: R-HSA-8856825Reactome: R-HSA-8856828 |
| Cellular Localisation | Cell MembranePeripheral Membrane ProteinNucleusMembraneCoated PitLocalized To Plasma Membrane Coated Pits |
| Alternative Antibody Names | Anti-Epidermal Growth Factor Receptor Substrate 15-Like 1 antibodyAnti-Eps15-Related Protein antibodyAnti-Eps15r antibodyAnti-EPS15L1 antibodyAnti-EPS15R antibody |
Information sourced from Uniprot.org