Anti-Recombinant-DUSP6 antibody [RM1B64] (STJA0026834)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal anti-Recombinant-Dual Specificity Protein Phosphatase 6 for use in FC, IF, IHC, IP and WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | FC/IF/IHC/IP/WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | RM1B64 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Protein A/G purified from cell culture supernatant |
| Dilution Range | FCM: 1:20-1:100, IF: 1:50-1:200, IHC: 1:100-1:200, IP: 1:20-1:50, WB: 1:1000-1:2000 |
| Formulation | 0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium Azide |
| Storage Instruction | Suitable for storage at +4°C between 1-2 weeks. For longer term store at-20°C for up to 12 months. |
Target Information
| Gene Symbol | DUSP6 |
| Gene ID | 1848 |
| Uniprot ID | DUS6_HUMAN |
Additional Info
| Post Translational Modifications | Ubiquitinated by the SCF(FBXO31) complex, leading to its proteasomal degradation. |
| Function | Dual specificity protein phosphatase, which mediates dephosphorylation and inactivation of MAP kinases. Has a specificity for the ERK family. Plays an important role in alleviating chronic postoperative pain. Necessary for the normal dephosphorylation of the long-lasting phosphorylated forms of spinal MAPK1/3 and MAP kinase p38 induced by peripheral surgery, which drives the resolution of acute postoperative allodynia. Also important for dephosphorylation of MAPK1/3 in local wound tissue, which further contributes to resolution of acute pain. Promotes cell differentiation by regulating MAPK1/MAPK3 activity and regulating the expression of AP1 transcription factors. |
| Protein Name | Dual Specificity Protein Phosphatase 6Dual Specificity Protein Phosphatase Pyst1Mitogen-Activated Protein Kinase Phosphatase 3Map Kinase Phosphatase 3Mkp-3 |
| Database Links | Reactome: R-HSA-112409Reactome: R-HSA-202670Reactome: R-HSA-5675221Reactome: R-HSA-9652817 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Dual Specificity Protein Phosphatase 6 antibodyAnti-Dual Specificity Protein Phosphatase Pyst1 antibodyAnti-Mitogen-Activated Protein Kinase Phosphatase 3 antibodyAnti-Map Kinase Phosphatase 3 antibodyAnti-Mkp-3 antibodyAnti-DUSP6 antibodyAnti-MKP3 antibodyAnti-PYST1 antibody |
Information sourced from Uniprot.org