Anti-Recombinant-DNPH1 antibody [RM1E19] (STJA0023013)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal anti-Recombinant-5-Hydroxymethyl-Dump N-Hydrolase for use in IF, IHC and WB in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IF/IHC/WB |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | RM1E19 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Protein A/G purified from cell culture supernatant |
| Dilution Range | IF: 1:50-1:200 |
| Formulation | 0.01M PBS |
| Storage Instruction | Suitable for storage at +4°C between 1-2 weeks. For longer term store at-20°C for up to 12 months. |
Target Information
| Gene Symbol | DNPH1 |
| Gene ID | 10591 |
| Uniprot ID | DNPH1_HUMAN |
Additional Info
| Function | Part of a nucleotide salvage pathway that eliminates epigenetically modified 5-hydroxymethyl-dCMP (hmdCMP) in a two-step process entailing deamination to cytotoxic 5-hydroxymethyl-dUMP (hmdUMP), followed by its hydrolysis into 5-hydroxymethyluracil (hmU) and 2-deoxy-D-ribose 5-phosphate (deoxyribosephosphate). Catalyzes the second step in that pathway, the hydrolysis of the N-glycosidic bond in hmdUMP, degrading this cytotoxic nucleotide to avoid its genomic integration. |
| Protein Name | 5-Hydroxymethyl-Dump N-Hydrolase2'-Deoxynucleoside 5'-Phosphate N-Hydrolase 1C-Myc-Responsive Protein Rcl |
| Database Links | Reactome: R-HSA-74259 |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Antibody Names | Anti-5-Hydroxymethyl-Dump N-Hydrolase antibodyAnti-2'-Deoxynucleoside 5'-Phosphate N-Hydrolase 1 antibodyAnti-C-Myc-Responsive Protein Rcl antibodyAnti-DNPH1 antibodyAnti-C6orf108 antibodyAnti-RCL antibody |
Information sourced from Uniprot.org