Anti-Recombinant-Cytokeratin 8 antibody (472-483) [E8-C6-B4] {FL594 Ex: 594 nm, Em: 615 nm} (STJA0040556)
SPECIFICATIONS
ClonalityMonoclonal
HostChicken
ConjugationFL594 Ex: 594 nm, Em: 615 nm
IsotypeIgY
ImmunogenC-terminal amino acids 472-483 of Human Cytokeratin 8
General Information
| Short Description | Chicken monoclonal anti-Recombinant-Cytokeratin 8 (472-483) for use in IHC and ICC in Bovine and Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/ICC |
| Host | Chicken |
| Reactivity | Bovine/Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | E8-C6-B4 |
| Isotype | IgY |
| Conjugation | FL594 Ex: 594 nm, Em: 615 nm |
| Concentration | 0.5 mg/mL |
| Purification | Purified by affinity chromatography |
| Dilution Range | ICC 1:500-1:2000 |
| Formulation | 1X PBS, 0.05% Sodium Azide pH 7.4 |
| Storage Instruction | Aliquot and store at โค-20ยฐC for long term storage. For short term storage, store at 2-8ยฐC. For maximum recovery of product, centrifuge the vial prior to removing the cap. |
Target Information
| Gene Symbol | KRT8 |
| Gene ID | 3856 |
| Uniprot ID | K2C8_HUMAN |
| Immunogen | C-terminal amino acids 472-483 of Human Cytokeratin 8 |
| Immunogen Region | 472-483 |
| Immunogen Sequence | Human |
| Specificity | No cross-reactivity reported |
Additional Info
| Tissue Specificity | Observed in muscle fibers accumulating in the costameres of myoplasm at the sarcolemma membrane in structures that contain dystrophin and spectrin. Expressed in gingival mucosa and hard palate of the oral cavity. |
| Post Translational Modifications | Phosphorylation on serine residues is enhanced during EGF stimulation and mitosis. Ser-74 phosphorylation plays an important role in keratin filament reorganization. O-glycosylated. O-GlcNAcylation at multiple sites increases solubility, and decreases stability by inducing proteasomal degradation. O-glycosylated (O-GlcNAcylated), in a cell cycle-dependent manner. |
| Function | Together with KRT19, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle. |
| Protein Name | Keratin - Type Ii Cytoskeletal 8Cytokeratin-8Ck-8Keratin-8K8Type-Ii Keratin Kb8 |
| Database Links | Reactome: R-HSA-6805567Reactome: R-HSA-6809371 |
| Cellular Localisation | CytoplasmNucleusNucleoplasmNucleus Matrix |
| Alternative Antibody Names | Anti-Keratin - Type Ii Cytoskeletal 8 antibodyAnti-Cytokeratin-8 antibodyAnti-Ck-8 antibodyAnti-Keratin-8 antibodyAnti-K8 antibodyAnti-Type-Ii Keratin Kb8 antibodyAnti-KRT8 antibodyAnti-CYK8 antibody |
Information sourced from Uniprot.org