Anti-Recombinant-Cytokeratin 8 antibody (472-483) [E8-C6-B4] {FL490 Ex: 491 nm, Em: 515 nm} (STJA0040554)

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STJA0040554-200
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Short Description :Chicken monoclonal anti-Recombinant-Cytokeratin 8 (472-483) for use in IHC and ICC in Bovine and Human samples. Datasheet included with dilution recommendations, and related reagents.
Applications:IHC/ICC
Host:Chicken
Reactivity:Bovine/Human
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality :Monoclonal
Clone ID :E8-C6-B4
Isotype:IgY
Conjugation:FL490 Ex: 491 nm, Em: 515 nm
Concentration:0.5 mg/mL
Purification:Purified by affinity chromatography
Dilution Range:ICC 1:500-1:2000
Formulation:1X PBS, 0.05% Sodium Azide pH 7.4
Storage Instruction:Aliquot and store at ≤-20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.
Gene Symbol:KRT8
Gene ID:3856
Uniprot ID:K2C8_HUMAN
Immunogen:C-terminal amino acids 472-483 of Human Cytokeratin 8
Immunogen Region:472-483
Immunogen Sequence:Human
Specificity:No cross-reactivity reported
Tissue Specificity Observed in muscle fibers accumulating in the costameres of myoplasm at the sarcolemma membrane in structures that contain dystrophin and spectrin. Expressed in gingival mucosa and hard palate of the oral cavity.
Post Translational Modifications Phosphorylation on serine residues is enhanced during EGF stimulation and mitosis. Ser-74 phosphorylation plays an important role in keratin filament reorganization. O-glycosylated. O-GlcNAcylation at multiple sites increases solubility, and decreases stability by inducing proteasomal degradation. O-glycosylated (O-GlcNAcylated), in a cell cycle-dependent manner.
Function Together with KRT19, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle.
Protein Name Keratin - Type Ii Cytoskeletal 8
Cytokeratin-8
Ck-8
Keratin-8
K8
Type-Ii Keratin Kb8
Database Links Reactome: R-HSA-6805567
Reactome: R-HSA-6809371
Cellular Localisation Cytoplasm
Nucleus
Nucleoplasm
Nucleus Matrix
Alternative Antibody Names Anti-Keratin - Type Ii Cytoskeletal 8 antibody
Anti-Cytokeratin-8 antibody
Anti-Ck-8 antibody
Anti-Keratin-8 antibody
Anti-K8 antibody
Anti-Type-Ii Keratin Kb8 antibody
Anti-KRT8 antibody
Anti-CYK8 antibody

Information sourced from Uniprot.org

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