Anti-Recombinant-Cytokeratin 17 antibody [SM0663] (STJA0010663)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG1
ImmunogenKLH conjugated Synthetic peptide corresponding to Human Cytokeratin 17
General Information
| Short Description | Mouse monoclonal anti-Recombinant-Cytokeratin 17 for use in WB, IHC and IF in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC/IF |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | SM0663 |
| Isotype | IgG1 |
| Conjugation | Unconjugated |
| Purification | Affinity purification |
| Dilution Range | WB (H) 1:500-1:2000IHC/IF (H) 1:500-1:1000 |
| Formulation | PBS with 0.15% ProClin300, 100 Mu g/mL BSA and 50% glycerol. |
| Storage Instruction | Store at-20C for up to one year, and avoid repeated freeze-thaw cycles. |
Target Information
| Gene Symbol | Krt17 |
| Gene ID | 16667 |
| Uniprot ID | K1C17_MOUSE |
| Immunogen | KLH conjugated Synthetic peptide corresponding to Human Cytokeratin 17 |
Additional Info
| Post Translational Modifications | Phosphorylation at Ser-44 occurs in a growth- and stress-dependent fashion in skin keratinocytes, it has no effect on filament organization. |
| Function | Type I keratin involved in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair. Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state. Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway. Involved in tissue repair. May be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial 'stem cells'. Acts as a promoter of epithelial proliferation by acting a regulator of immune response in skin: promotes Th1/Th17-dominated immune environment contributing to the development of basaloid skin tumors. May act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions being a major target for autoreactive T-cells and hence causing their proliferation. |
| Protein Name | Keratin - Type I Cytoskeletal 17Cytokeratin-17Ck-17Keratin-17K17 |
| Database Links | Reactome: R-MMU-6805567Reactome: -MMU-6809371 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Keratin - Type I Cytoskeletal 17 antibodyAnti-Cytokeratin-17 antibodyAnti-Ck-17 antibodyAnti-Keratin-17 antibodyAnti-K17 antibodyAnti-Krt17 antibodyAnti-Krt1-17 antibody |
Information sourced from Uniprot.org