Anti-Recombinant-CUBN/Cubilin antibody [RM1A16] (STJA0026687)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal anti-Recombinant-Cubilin for use in IHC and WB in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/WB |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | RM1A16 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Protein A/G purified from cell culture supernatant |
| Dilution Range | IHC: 1:100-1:200, WB: 1:1000-1:2000 |
| Formulation | 0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium Azide |
| Storage Instruction | Suitable for storage at +4°C between 1-2 weeks. For longer term store at-20°C for up to 12 months. |
Target Information
| Gene Symbol | CUBN |
| Gene ID | 8029 |
| Uniprot ID | CUBN_HUMAN |
Additional Info
| Post Translational Modifications | The precursor is cleaved by a trans-Golgi proteinase furin, removing a propeptide. N-glycosylated. |
| Function | Endocytic receptor which plays a role in lipoprotein, vitamin and iron metabolism by facilitating their uptake. Acts together with LRP2 to mediate endocytosis of high-density lipoproteins, GC, hemoglobin, ALB, TF and SCGB1A1. Acts together with AMN to mediate endocytosis of the CBLIF-cobalamin complex. Binds to ALB, MB, Kappa and lambda-light chains, TF, hemoglobin, GC, SCGB1A1, APOA1, high density lipoprotein, and the CBLIF-cobalamin complex. Ligand binding requires calcium. Serves as important transporter in several absorptive epithelia, including intestine, renal proximal tubules and embryonic yolk sac. May play an important role in the development of the peri-implantation embryo through internalization of APOA1 and cholesterol. Binds to LGALS3 at the maternal-fetal interface. |
| Protein Name | Cubilin460 Kda ReceptorIntestinal Intrinsic Factor ReceptorIntrinsic Factor-Cobalamin ReceptorIntrinsic Factor-Vitamin B12 Receptor |
| Database Links | Reactome: R-HSA-196791Reactome: R-HSA-3359462Reactome: R-HSA-3359463Reactome: R-HSA-8964011Reactome: R-HSA-9758881 |
| Cellular Localisation | Apical Cell MembranePeripheral Membrane ProteinCell MembraneMembraneCoated PitEndosomeLysosome MembraneLacks A Transmembrane Domain And Depends On Interaction With Amn For Location At The Plasma MembraneColocalizes With Amn And Lrp2 In The Endocytotic Apparatus Of Epithelial Cells |
| Alternative Antibody Names | Anti-Cubilin antibodyAnti-460 Kda Receptor antibodyAnti-Intestinal Intrinsic Factor Receptor antibodyAnti-Intrinsic Factor-Cobalamin Receptor antibodyAnti-Intrinsic Factor-Vitamin B12 Receptor antibodyAnti-CUBN antibodyAnti-IFCR antibody |
Information sourced from Uniprot.org