Anti-Recombinant-CRADD antibody [RM2B38] (STJA0025111)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal anti-Recombinant-Death Domain-Containing Protein Cradd for use in IF, IP and WB in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IF/IP/WB |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | RM2B38 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Protein A/G purified from cell culture supernatant |
| Dilution Range | IF: 1:50-1:200, IP: 1:20, WB: 1:500-1:1000 |
| Formulation | 0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium Azide |
| Storage Instruction | Suitable for storage at +4°C between 1-2 weeks. For longer term store at-20°C for up to 12 months. |
Target Information
| Gene Symbol | CRADD |
| Gene ID | 8738 |
| Uniprot ID | CRADD_HUMAN |
Additional Info
| Function | Adapter protein that associates with PIDD1 and the caspase CASP2 to form the PIDDosome, a complex that activates CASP2 and triggers apoptosis. Also recruits CASP2 to the TNFR-1 signaling complex through its interaction with RIPK1 and TRADD and may play a role in the tumor necrosis factor-mediated signaling pathway. |
| Protein Name | Death Domain-Containing Protein CraddCaspase And Rip Adapter With Death DomainRip-Associated Protein With A Death Domain |
| Database Links | Reactome: R-HSA-6803207 |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Antibody Names | Anti-Death Domain-Containing Protein Cradd antibodyAnti-Caspase And Rip Adapter With Death Domain antibodyAnti-Rip-Associated Protein With A Death Domain antibodyAnti-CRADD antibodyAnti-RAIDD antibody |
Information sourced from Uniprot.org