Anti-Recombinant-CPS1 antibody [RM1U19] (STJA0024399)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal anti-Recombinant-Carbamoyl-Phosphate Synthase Ammonia-Mitochondrial for use in IHC, IP and WB in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/IP/WB |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | RM1U19 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Protein A/G purified from cell culture supernatant |
| Dilution Range | IHC: 1:50-1:100 |
| Formulation | 0.01M PBS |
| Storage Instruction | Suitable for storage at +4°C between 1-2 weeks. For longer term store at-20°C for up to 12 months. |
Target Information
| Gene Symbol | CPS1 |
| Gene ID | 1373 |
| Uniprot ID | CPSM_HUMAN |
Additional Info
| Post Translational Modifications | Undergoes proteolytic cleavage in the C-terminal region corresponding to the loss of approximately 12 AA residues from the C-terminus. Succinylated at Lys-287 and Lys-1291. Desuccinylated at Lys-1291 by SIRT5, leading to activation. Glutarylated. Glutarylation levels increase during fasting. Deglutarylated by SIRT5 at Lys-55, Lys-219, Lys-412, Lys-889, Lys-892, Lys-915, Lys-1360 and Lys-1486, leading to activation. |
| Function | Involved in the urea cycle of ureotelic animals where the enzyme plays an important role in removing excess ammonia from the cell. |
| Protein Name | Carbamoyl-Phosphate Synthase Ammonia - MitochondrialCarbamoyl-Phosphate Synthetase ICpsase I |
| Database Links | Reactome: R-HSA-70635 |
| Cellular Localisation | MitochondrionNucleusNucleolusCell MembranePeripheral Membrane ProteinExtracellular SideLocalizes To The Cell Surface Of Hepatocytes |
| Alternative Antibody Names | Anti-Carbamoyl-Phosphate Synthase Ammonia - Mitochondrial antibodyAnti-Carbamoyl-Phosphate Synthetase I antibodyAnti-Cpsase I antibodyAnti-CPS1 antibody |
Information sourced from Uniprot.org