Anti-Recombinant-CES1 antibody [RM1S20] (STJA0024202)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal anti-Recombinant-Liver Carboxylesterase 1 for use in FC, IP and WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | FC/IP/WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | RM1S20 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Protein A/G purified from cell culture supernatant |
| Dilution Range | FCM: 1:20-1:100 |
| Formulation | 0.01M PBS |
| Storage Instruction | Suitable for storage at +4°C between 1-2 weeks. For longer term store at-20°C for up to 12 months. |
Target Information
| Gene Symbol | CES1 |
| Gene ID | 1066 |
| Uniprot ID | EST1_HUMAN |
Additional Info
| Post Translational Modifications | Contains sialic acid. Cleavage of the signal sequence can occur at 2 positions, either between Trp-17 and Gly-18 or between Gly-18 and His-19. |
| Function | Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Hydrolyzes aromatic and aliphatic esters, but has no catalytic activity toward amides or a fatty acyl-CoA ester. Hydrolyzes the methyl ester group of cocaine to form benzoylecgonine. Catalyzes the transesterification of cocaine to form cocaethylene. Displays fatty acid ethyl ester synthase activity, catalyzing the ethyl esterification of oleic acid to ethyloleate. Converts monoacylglycerides to free fatty acids and glycerol. Hydrolyzes of 2-arachidonoylglycerol and prostaglandins. Hydrolyzes cellular cholesteryl esters to free cholesterols and promotes reverse cholesterol transport (RCT) by facilitating both the initial and final steps in the process. First of all, allows free cholesterol efflux from macrophages to extracellular cholesterol acceptors and secondly, releases free cholesterol from lipoprotein-delivered cholesteryl esters in the liver for bile acid synthesis or direct secretion into the bile. |
| Protein Name | Liver Carboxylesterase 1Acyl-Coenzyme A -Cholesterol AcyltransferaseAcatBrain Carboxylesterase Hbr1Carboxylesterase 1Ce-1Hce-1Cholesteryl Ester HydrolaseCehCocaine CarboxylesteraseEgasynHmseMethylumbelliferyl-Acetate Deacetylase 1Monocyte/Macrophage Serine EsteraseRetinyl Ester HydrolaseRehSerine Esterase 1Triacylglycerol HydrolaseTgh |
| Database Links | Reactome: R-HSA-2022377Reactome: R-HSA-211945Reactome: R-HSA-5578768Reactome: R-HSA-9749641 |
| Cellular Localisation | Endoplasmic Reticulum LumenCytoplasmLipid DropletMoves From Cytoplasm To Lipid Droplets Upon Lipid LoadingAssociates With Lipid Droplets Independently Of Triglycerides (Tg) Content Of The Droplets And Hydrolyzes Cholesteryl Esters More Efficiently From Mixed Droplets |
| Alternative Antibody Names | Anti-Liver Carboxylesterase 1 antibodyAnti-Acyl-Coenzyme A -Cholesterol Acyltransferase antibodyAnti-Acat antibodyAnti-Brain Carboxylesterase Hbr1 antibodyAnti-Carboxylesterase 1 antibodyAnti-Ce-1 antibodyAnti-Hce-1 antibodyAnti-Cholesteryl Ester Hydrolase antibodyAnti-Ceh antibodyAnti-Cocaine Carboxylesterase antibodyAnti-Egasyn antibodyAnti-Hmse antibodyAnti-Methylumbelliferyl-Acetate Deacetylase 1 antibodyAnti-Monocyte/Macrophage Serine Esterase antibodyAnti-Retinyl Ester Hydrolase antibodyAnti-Reh antibodyAnti-Serine Esterase 1 antibodyAnti-Triacylglycerol Hydrolase antibodyAnti-Tgh antibodyAnti-CES1 antibodyAnti-CES2 antibodyAnti-SES1 antibody |
Information sourced from Uniprot.org