Anti-Recombinant-CD41/ITGA2B antibody [RM1L64] (STJA0023652)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal anti-Recombinant-Integrin Alpha-Iib for use in WB in Human and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | RM1L64 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Protein A/G purified from cell culture supernatant |
| Dilution Range | WB: 1:500-1:1000 |
| Formulation | 0.01M PBS |
| Storage Instruction | Suitable for storage at +4°C between 1-2 weeks. For longer term store at-20°C for up to 12 months. |
Target Information
| Gene Symbol | ITGA2B |
| Gene ID | 3674 |
| Uniprot ID | ITA2B_HUMAN |
Additional Info
| Post Translational Modifications | Integrin alpha-IIb heavy chain: Cleaved by ELANE.the cleavage promotes activation of platelet fibrinogen receptor integrin alpha-IIb/beta-3. |
| Function | Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface. |
| Protein Name | Integrin Alpha-IibGpalpha IibGpiibPlatelet Membrane Glycoprotein IibCd Antigen Cd41 Cleaved Into - Integrin Alpha-Iib Heavy Chain - Integrin Alpha-Iib Light Chain - Form 1 - Integrin Alpha-Iib Light Chain - Form 2 |
| Database Links | Reactome: R-HSA-114608Reactome: R-HSA-216083Reactome: R-HSA-3000178Reactome: R-HSA-354192Reactome: R-HSA-354194Reactome: R-HSA-372708Reactome: R-HSA-445144Reactome: R-HSA-5674135Reactome: R-HSA-6802946Reactome: R-HSA-6802948Reactome: R-HSA-6802952Reactome: R-HSA-6802955Reactome: R-HSA-8936459Reactome: R-HSA-9649948Reactome: R-HSA-9656223 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Integrin Alpha-Iib antibodyAnti-Gpalpha Iib antibodyAnti-Gpiib antibodyAnti-Platelet Membrane Glycoprotein Iib antibodyAnti-Cd Antigen Cd41 Cleaved Into - Integrin Alpha-Iib Heavy Chain - Integrin Alpha-Iib Light Chain - Form 1 - Integrin Alpha-Iib Light Chain - Form 2 antibodyAnti-ITGA2B antibodyAnti-GP2B antibodyAnti-ITGAB antibody |
Information sourced from Uniprot.org