Anti-Recombinant-CD4 antibody [SR0554] (STJA0010554)

Name: Anti-Recombinant-CD4 antibody [SR0554] (STJA0010554)
SKU: STJA0010554
Availability: InStock

⇓ Datasheet ⇓ SDS

SPECIFICATIONS

ClonalityMonoclonal

HostRabbit

ConjugationUnconjugated

IsotypeIgG

ImmunogenKLH conjugated Synthetic peptide corresponding to Mouse CD4

STJA0010554

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General Information

Short Description	Rabbit monoclonal anti-Recombinant-CD4 for use in WB, IHC and IF in Mouse samples. Datasheet included with dilution recommendations, and related reagents.
Applications	WB/IHC/IF
Host	Rabbit
Reactivity	Mouse
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Product Properties

Clonality	Monoclonal
Clone ID	SR0554
Isotype	IgG
Conjugation	Unconjugated
Purification	Affinity purification
Dilution Range	WB (M) 1:500-1:1000 IHC/IF (M) 1:200-1:600
Formulation	PBS with 0.15% ProClin300, 100 Mu g/mL BSA and 50% glycerol.
Storage Instruction	Store at-20C for up to one year, and avoid repeated freeze-thaw cycles.

Target Information

Gene Symbol	Cd4
Gene ID	12504
Uniprot ID	CD4_MOUSE
Immunogen	KLH conjugated Synthetic peptide corresponding to Mouse CD4

Additional Info

Post Translational Modifications	Palmitoylation and association with LCK contribute to the enrichment of CD4 in lipid rafts. Phosphorylated by PKC.phosphorylation plays an important role for CD4 internalization.
Function	Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of T-helper cells. In other cells such as macrophages or NK cells, plays a role in differentiation/activation, cytokine expression and cell migration in a TCR/LCK-independent pathway. Participates in the development of T-helper cells in the thymus and triggers the differentiation of monocytes into functional mature macrophages.
Protein Name	T-Cell Surface Glycoprotein Cd4 T-Cell Differentiation Antigen L3t4 T-Cell Surface Antigen T4/Leu-3 Cd Antigen Cd4
Database Links	Reactome: R-MMU-1462054 Reactome: -MMU-202424 Reactome: -MMU-202427 Reactome: -MMU-202430 Reactome: -MMU-202433 Reactome: -MMU-389948 Reactome: -MMU-449836 Reactome: -MMU-8856825 Reactome: -MMU-8856828
Cellular Localisation	Cell Membrane Single-Pass Type I Membrane Protein
Alternative Antibody Names	Anti-T-Cell Surface Glycoprotein Cd4 antibody Anti-T-Cell Differentiation Antigen L3t4 antibody Anti-T-Cell Surface Antigen T4/Leu-3 antibody Anti-Cd Antigen Cd4 antibody Anti-Cd4 antibody

Information sourced from Uniprot.org

Citations

View product citations for antibody STJA0010554 on CiteAb