| Host: | Rabbit |
| Applications: | IHC/IF |
| Reactivity: | Human/Mouse/Rat/Monkey |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit monoclonal antibody anti-Recombinant-CD163 is suitable for use in Immunohistochemistry and Immunofluorescence research applications. |
| Clonality : | Monoclonal |
| Clone ID : | SR0659 |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.15% ProClin300, 100 Mu g/mL BSA and 50% glycerol. |
| Purification: | Affinity purification |
| Dilution Range: | IHC/IF (H, M, R, Mk) 1:300-1:600 |
| Storage Instruction: | Store at-20C for up to one year, and avoid repeated freeze-thaw cycles. |
| Gene Symbol: | Cd163 |
| Gene ID: | 93671 |
| Uniprot ID: | C163A_MOUSE |
| Immunogen: | Recombinant protein corresponding to Mouse CD163 |
| Post Translational Modifications | A soluble form (sCD163) is produced by proteolytic shedding which can be induced by lipopolysaccharide, phorbol ester and Fc region of immunoglobulin gamma. This cleavage is dependent on protein kinase C and tyrosine kinases and can be blocked by protease inhibitors. The shedding is inhibited by the tissue inhibitor of metalloproteinase TIMP3, and thus probably induced by membrane-bound metalloproteinases ADAMs. |
| Function | Involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1. After shedding, the soluble form (sCD163) may play an anti-inflammatory role. |
| Protein Name | Scavenger Receptor Cysteine-Rich Type 1 Protein M130 Cd Antigen Cd163 Cleaved Into - Soluble Cd163 Scd163 |
| Database Links | Reactome: R-MMU-2168880 |
| Cellular Localisation | Soluble Cd163: Secreted Cell Membrane Single-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Scavenger Receptor Cysteine-Rich Type 1 Protein M130 antibody Anti-Cd Antigen Cd163 Cleaved Into - Soluble Cd163 antibody Anti-Scd163 antibody Anti-Cd163 antibody Anti-M130 antibody |
Information sourced from Uniprot.org