Anti-Recombinant-CAD antibody [RM1T38] (STJA0024319)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal anti-Recombinant-Multifunctional Protein Cad for use in FC, IF, IP and WB in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | FC/IF/IP/WB |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | RM1T38 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Protein A/G purified from cell culture supernatant |
| Dilution Range | FCM: 1:20-1:100 |
| Formulation | 0.01M PBS |
| Storage Instruction | Suitable for storage at +4°C between 1-2 weeks. For longer term store at-20°C for up to 12 months. |
Target Information
| Gene Symbol | CAD |
| Gene ID | 790 |
| Uniprot ID | PYR1_HUMAN |
Additional Info
| Function | Multifunctional protein that encodes the first 3 enzymatic activities of the de novo pyrimidine pathway: carbamoylphosphate synthetase (CPSase.EC 6.3.5.5), aspartate transcarbamylase (ATCase.EC 2.1.3.2) and dihydroorotase (DHOase.EC 3.5.2.3). The CPSase-function is accomplished in 2 steps, by a glutamine-dependent amidotransferase activity (GATase) that binds and cleaves glutamine to produce ammonia, followed by an ammonium-dependent carbamoyl phosphate synthetase, which reacts with the ammonia, hydrogencarbonate and ATP to form carbamoyl phosphate. The endogenously produced carbamoyl phosphate is sequestered and channeled to the ATCase active site. ATCase then catalyzes the formation of carbamoyl-L-aspartate from L-aspartate and carbamoyl phosphate. In the last step, DHOase catalyzes the cyclization of carbamoyl aspartate to dihydroorotate. |
| Protein Name | Multifunctional Protein CadCarbamoyl Phosphate Synthetase 2-Aspartate Transcarbamylase-Dihydroorotase Includes - Glutamine-Dependent Carbamoyl Phosphate Synthase - Glutamine AmidotransferaseGataseGlnase - Ammonium-Dependent Carbamoyl Phosphate SynthaseCpsCpsase - Aspartate Carbamoyltransferase - Dihydroorotase |
| Database Links | Reactome: R-HSA-500753 |
| Cellular Localisation | CytoplasmNucleusCytosolic And Unphosphorylated In Resting CellsTranslocates To The Nucleus In Response To Egf StimulationNuclear Import Promotes Optimal Cell Growth |
| Alternative Antibody Names | Anti-Multifunctional Protein Cad antibodyAnti-Carbamoyl Phosphate Synthetase 2-Aspartate Transcarbamylase-Dihydroorotase Includes - Glutamine-Dependent Carbamoyl Phosphate Synthase - Glutamine Amidotransferase antibodyAnti-Gatase antibodyAnti-Glnase - Ammonium-Dependent Carbamoyl Phosphate Synthase antibodyAnti-Cps antibodyAnti-Cpsase - Aspartate Carbamoyltransferase - Dihydroorotase antibodyAnti-CAD antibody |
Information sourced from Uniprot.org