Anti-Recombinant-CABP1 antibody [RM1B77] (STJA0026847)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal anti-Recombinant-Calcium-Binding Protein 1 for use in IF and WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IF/WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | RM1B77 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Protein A/G purified from cell culture supernatant |
| Dilution Range | IF: 1:50-1:200, WB: 1:1000-1:2000 |
| Formulation | 0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium Azide |
| Storage Instruction | Suitable for storage at +4°C between 1-2 weeks. For longer term store at-20°C for up to 12 months. |
Target Information
| Gene Symbol | CABP1 |
| Gene ID | 9478 |
| Uniprot ID | CABP1_HUMAN |
Additional Info
| Post Translational Modifications | Phosphorylated. The phosphorylation regulates the activity. |
| Function | Modulates calcium-dependent activity of inositol 1,4,5-triphosphate receptors (ITPRs). Inhibits agonist-induced intracellular calcium signaling. Enhances inactivation and does not support calcium-dependent facilitation of voltage-dependent P/Q-type calcium channels. Causes calcium-dependent facilitation and inhibits inactivation of L-type calcium channels by binding to the same sites as calmodulin in the C-terminal domain of CACNA1C, but has an opposite effect on channel function. Suppresses the calcium-dependent inactivation of CACNA1D. Inhibits TRPC5 channels. Prevents NMDA receptor-induced cellular degeneration. Required for the normal transfer of light signals through the retina. |
| Protein Name | Calcium-Binding Protein 1Cabp1CalbrainCaldendrin |
| Database Links | Reactome: R-HSA-9662360 |
| Cellular Localisation | CytoplasmCytoskeletonPerinuclear RegionCell MembraneLipid-AnchorCytoplasmic SideGolgi ApparatusPostsynaptic DensityL-Cabp1 Is Associated Most Likely With The Cytoskeletal StructuresWhereas S-Cabp1 Is Localized At Or Near The Plasma MembraneIsoform L-Cabp1: CytoplasmIsoform S-Cabp1: CytoplasmCell CortexS-Cabp1 Is Localized At Or Near The Plasma Membrane |
| Alternative Antibody Names | Anti-Calcium-Binding Protein 1 antibodyAnti-Cabp1 antibodyAnti-Calbrain antibodyAnti-Caldendrin antibodyAnti-CABP1 antibody |
Information sourced from Uniprot.org