Anti-Recombinant-BNIP3L antibody [RM1E46] (STJA0023040)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal anti-Recombinant-Bcl2/Adenovirus E1b 19 Kda Protein-Interacting Protein 3-Like for use in IHC and WB in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/WB |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | RM1E46 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Protein A/G purified from cell culture supernatant |
| Dilution Range | IHC: 1:50-1:100 |
| Formulation | 0.01M PBS |
| Storage Instruction | Suitable for storage at +4°C between 1-2 weeks. For longer term store at-20°C for up to 12 months. |
Target Information
| Gene Symbol | BNIP3L |
| Gene ID | 665 |
| Uniprot ID | BNI3L_HUMAN |
Additional Info
| Function | Induces apoptosis. Interacts with viral and cellular anti-apoptosis proteins. Can overcome the suppressors BCL-2 and BCL-XL, although high levels of BCL-XL expression will inhibit apoptosis. Inhibits apoptosis induced by BNIP3. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates in mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. May function as a tumor suppressor. |
| Protein Name | Bcl2/Adenovirus E1b 19 Kda Protein-Interacting Protein 3-LikeAdenovirus E1b19k-Binding Protein B5Bcl2/Adenovirus E1b 19 Kda Protein-Interacting Protein 3aNip3-Like Protein XNip3l |
| Database Links | Reactome: R-HSA-6803204 |
| Cellular Localisation | Nucleus EnvelopeEndoplasmic ReticulumMitochondrion Outer MembraneMembraneSingle-Pass Membrane ProteinColocalizes With Spata18 At The Mitochondrion Outer Membrane |
| Alternative Antibody Names | Anti-Bcl2/Adenovirus E1b 19 Kda Protein-Interacting Protein 3-Like antibodyAnti-Adenovirus E1b19k-Binding Protein B5 antibodyAnti-Bcl2/Adenovirus E1b 19 Kda Protein-Interacting Protein 3a antibodyAnti-Nip3-Like Protein X antibodyAnti-Nip3l antibodyAnti-BNIP3L antibodyAnti-BNIP3A antibodyAnti-BNIP3H antibodyAnti-NIX antibody |
Information sourced from Uniprot.org