Anti-Recombinant-BIRC5/Survivin antibody [RM1C18] (STJA0026887)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal anti-Recombinant-BIRC5/Survivin for use in IHC, IP and WB in Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/IP/WB |
| Host | Rabbit |
| Reactivity | Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | RM1C18 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Protein A/G purified from cell culture supernatant |
| Dilution Range | IHC: 1:100-1:200, IP: 1:20-1:50, WB: 1:1000-1:2000 |
| Formulation | 0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium Azide |
| Storage Instruction | Suitable for storage at +4°C between 1-2 weeks. For longer term store at-20°C for up to 12 months. |
Target Information
| Gene Symbol | Birc5 |
| Gene ID | 11799 |
| Uniprot ID | BIRC5_MOUSE |
Additional Info
| Function | Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis. Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis. Acts as an important regulator of the localization of this complex.directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with polymerized microtubules. Involved in the recruitment of CPC to centromeres during early mitosis via association with histone H3 phosphorylated at 'Thr-3' (H3pT3) during mitosis. The complex with RAN plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. May counteract a default induction of apoptosis in G2/M phase. The acetylated form represses STAT3 transactivation of target gene promoters. May play a role in neoplasia. Inhibitor of CASP3 and CASP7. Essential for the maintenance of mitochondrial integrity and function. |
| Protein Name | Baculoviral Iap Repeat-Containing Protein 5Apoptosis Inhibitor 4Apoptosis Inhibitor SurvivinTiap |
| Database Links | |
| Cellular Localisation | CytoplasmNucleusChromosomeCentromereCytoskeletonSpindleKinetochoreMidbodyLocalizes At The Centromeres From Prophase To MetaphaseAt The Spindle Midzone During Anaphase And A The Midbody During Telophase And CytokinesisAccumulates In The Nucleus Upon Treatment With Leptomycin B (Lmb)A Xpo1/Crm1 Nuclear Export InhibitorLocalizes On Chromosome Arms And Inner Centromeres From Prophase Through MetaphaseLocalizes To Kinetochores In MetaphaseDistributes To The Midzone Microtubules In Anaphase And At TelophaseLocalizes Exclusively To The MidbodyColocalizes With Aurkb At Mitotic ChromosomesAcetylation At Lys-129 Directs Its Localization To The Nucleus By Enhancing Homodimerization And Thereby Inhibiting Xpo1/Crm1-Mediated Nuclear Export |
| Alternative Antibody Names | Anti-Baculoviral Iap Repeat-Containing Protein 5 antibodyAnti-Apoptosis Inhibitor 4 antibodyAnti-Apoptosis Inhibitor Survivin antibodyAnti-Tiap antibodyAnti-Birc5 antibodyAnti-Api4 antibodyAnti-Iap4 antibody |
Information sourced from Uniprot.org