Anti-Recombinant-BCL11B antibody [RM2S33] (STJA0026591)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal anti-Recombinant-B-Cell Lymphoma/Leukemia 11b for use in WB in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | RM2S33 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Protein A/G purified from cell culture supernatant |
| Dilution Range | WB: 1:500-1:1000 |
| Formulation | 0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium Azide |
| Storage Instruction | Suitable for storage at +4°C between 1-2 weeks. For longer term store at-20°C for up to 12 months. |
Target Information
| Gene Symbol | BCL11B |
| Gene ID | 64919 |
| Uniprot ID | BC11B_HUMAN |
Additional Info
| Post Translational Modifications | Sumoylated with SUMO1. |
| Function | Key regulator of both differentiation and survival of T-lymphocytes during thymocyte development in mammals. Essential in controlling the responsiveness of hematopoietic stem cells to chemotactic signals by modulating the expression of the receptors CCR7 and CCR9, which direct the movement of progenitor cells from the bone marrow to the thymus. Is a regulator of IL2 promoter and enhances IL2 expression in activated CD4(+) T-lymphocytes. Tumor-suppressor that represses transcription through direct, TFCOUP2-independent binding to a GC-rich response element. May also function in the P53-signaling pathway. |
| Protein Name | B-Cell Lymphoma/Leukemia 11bBcl-11bB-Cell Cll/Lymphoma 11bCoup-Tf-Interacting Protein 2Radiation-Induced Tumor Suppressor Gene 1 ProteinHrit1 |
| Database Links | |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-B-Cell Lymphoma/Leukemia 11b antibodyAnti-Bcl-11b antibodyAnti-B-Cell Cll/Lymphoma 11b antibodyAnti-Coup-Tf-Interacting Protein 2 antibodyAnti-Radiation-Induced Tumor Suppressor Gene 1 Protein antibodyAnti-Hrit1 antibodyAnti-BCL11B antibodyAnti-CTIP2 antibodyAnti-RIT1 antibody |
Information sourced from Uniprot.org