Anti-Recombinant-ATP7B antibody [RM1V25] (STJA0024504)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal anti-Recombinant-Copper-Transporting Atpase 2 for use in FC, IF and WB in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | FC/IF/WB |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | RM1V25 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Protein A/G purified from cell culture supernatant |
| Dilution Range | FCM: 1:20-1:100 |
| Formulation | 0.01M PBS |
| Storage Instruction | Suitable for storage at +4°C between 1-2 weeks. For longer term store at-20°C for up to 12 months. |
Target Information
| Gene Symbol | ATP7B |
| Gene ID | 540 |
| Uniprot ID | ATP7B_HUMAN |
Additional Info
| Post Translational Modifications | Isoform 1 may be proteolytically cleaved at the N-terminus to produce the WND/140 kDa form. |
| Function | Copper ion transmembrane transporter involved in the export of copper out of the cells. It is involved in copper homeostasis in the liver, where it ensures the efflux of copper from hepatocytes into the bile in response to copper overload. |
| Protein Name | Copper-Transporting Atpase 2Copper Pump 2Wilson Disease-Associated Protein Cleaved Into - Wnd/140 Kda |
| Database Links | Reactome: R-HSA-936837 |
| Cellular Localisation | Golgi ApparatusTrans-Golgi Network MembraneMulti-Pass Membrane ProteinLate EndosomePredominantly Found In The Trans-Golgi Network (Tgn)Localized In The Trans-Golgi Network Under Low Copper ConditionsRedistributes To Cytoplasmic Vesicles When Cells Are Exposed To Elevated Copper LevelsAnd Then Recycles Back To The Trans-Golgi Network When Copper Is RemovedIsoform 1: Golgi Apparatus MembraneIsoform 2: CytoplasmWnd/140 Kda: Mitochondrion |
| Alternative Antibody Names | Anti-Copper-Transporting Atpase 2 antibodyAnti-Copper Pump 2 antibodyAnti-Wilson Disease-Associated Protein Cleaved Into - Wnd/140 Kda antibodyAnti-ATP7B antibodyAnti-PWD antibodyAnti-WC1 antibodyAnti-WND antibody |
Information sourced from Uniprot.org