Anti-Recombinant-ADA/Adenosine deaminase antibody [RM1H46] (STJA0023337)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal anti-Recombinant-Adenosine Deaminase for use in IF, IP and WB in Human and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IF/IP/WB |
| Host | Rabbit |
| Reactivity | Human/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | RM1H46 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Protein A/G purified from cell culture supernatant |
| Dilution Range | IF: 1:50-1:200 |
| Formulation | 0.01M PBS |
| Storage Instruction | Suitable for storage at +4°C between 1-2 weeks. For longer term store at-20°C for up to 12 months. |
Target Information
| Gene Symbol | ADA |
| Gene ID | 100 |
| Uniprot ID | ADA_HUMAN |
Additional Info
| Function | Catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine. Plays an important role in purine metabolism and in adenosine homeostasis. Modulates signaling by extracellular adenosine, and so contributes indirectly to cellular signaling events. Acts as a positive regulator of T-cell coactivation, by binding DPP4. Its interaction with DPP4 regulates lymphocyte-epithelial cell adhesion. Enhances dendritic cell immunogenicity by affecting dendritic cell costimulatory molecule expression and cytokines and chemokines secretion. Enhances CD4+ T-cell differentiation and proliferation. Acts as a positive modulator of adenosine receptors ADORA1 and ADORA2A, by enhancing their ligand affinity via conformational change. Stimulates plasminogen activation. Plays a role in male fertility. Plays a protective role in early postimplantation embryonic development. Also responsible for the deamination of cordycepin (3'-deoxyadenosine), a fungal natural product that shows antitumor, antibacterial, antifungal, antivirus, and immune regulation properties. |
| Protein Name | Adenosine DeaminaseAdenosine Aminohydrolase |
| Database Links | Reactome: R-HSA-74217Reactome: R-HSA-9734735Reactome: R-HSA-9755088 |
| Cellular Localisation | Cell MembranePeripheral Membrane ProteinExtracellular SideCell JunctionCytoplasmic Vesicle LumenCytoplasmLysosomeColocalized With Dpp4 At The Cell Surface |
| Alternative Antibody Names | Anti-Adenosine Deaminase antibodyAnti-Adenosine Aminohydrolase antibodyAnti-ADA antibodyAnti-ADA1 antibody |
Information sourced from Uniprot.org