| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:200-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | RDM1 |
| Gene ID: | 201299 |
| Uniprot ID: | RDM1_HUMAN |
| Immunogen Region: | 125-284 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 125-284 of human RDM1 (NP_663629.1). |
| Immunogen Sequence: | NGCSKRIIKLQELSDLEERE NEDSMVPLPKQSLKFFCALE VVLPSCDCRSPGIGLVEEPM DKVEEGPLSFLMKRKTAQKL AIQKALSDAFQKLLIVVLES GKIAVEYRPSEDIVGVRCEE ELHGLIQVPCSPWKQYGQEE EGYLSDFSLEEEEFRLPELD |
| Tissue Specificity | Expressed in testis. |
| Function | May confer resistance to the antitumor agent cisplatin. Binds to DNA and RNA. |
| Protein Name | Rad52 Motif-Containing Protein 1Rad52 Homolog B |
| Cellular Localisation | NucleusCytoplasmNucleolusIsoform 3 And Isoform 10 Are Predominantly Nuclear And NucleolarAfter Treatment With Proteasomal Inhibitors And Mild Heat-Shock StressIsoform 1Isoform 3Isoform 5Isoform 7Isoform 8 And Isoform 10 Are Relocalized To The Nucleolus As Dot-Like Or Irregular Subnuclear StructuresIsoform 1 Colocalized With Nuclear Promyelocytic Leukemia (Pml) And Cajal Bodies (Cb)This Association With Nuclear Bodies Is Enhanced In Response To Proteotoxic StressBut Not Isoform 1 And Isoform 5Is Relocalized In Nucleolar Caps During Transcriptional ArrestIsoform 1: CytoplasmPml BodyCajal BodyIsoform 1 Is Predominantly Cytoplasmic |
| Alternative Antibody Names | Anti-Rad52 Motif-Containing Protein 1 antibodyAnti-Rad52 Homolog B antibodyAnti-RDM1 antibodyAnti-RAD52B antibody |
Information sourced from Uniprot.org
