Anti-BMP1 antibody (284-296) (STJ73107)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-BMP1 (284-296) is suitable for use in ELISA, Western Blot and Immunohistochemistry research applications. |
| Applications | Pep-ELISA/WB/IHC |
| Host | Goat |
| Reactivity | Human/Mouse/Rat/Dog/Pig/Cow |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:128000.WB: Approx 75-80kDa band observed in Human Liver lysates and in lysates of cell. lines HeLa, Jurkat, MCF7, NIH3T3 and PC12 (calculated MW of 82.9kDa according to Human NP_001190.1 and, 93 |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20°C on receipt and minimise freeze-thaw cycles. |
Target Information
| Gene Symbol | BMP1 |
| Gene ID | 649 |
| Uniprot ID | BMP1_HUMAN |
| Accession Number | NP_001190.1; NP_006120.1 |
| Immunogen Region | 284-296 |
| Immunogen Sequence | DTIVPKYEVNGVK |
| Specificity | This antibody is expected to recognize both reported isoforms (NP_001190.1; NP_006120.1). |
Additional Info
| Post Translational Modifications | Proteolytically activated in the trans-Golgi network by furin-like/paired basic proprotein convertases, cleavage is not required for secretion. |
| Function | Metalloprotease that plays key roles in regulating the formation of the extracellular matrix (ECM) via processing of various precursor proteins into mature functional enzymes or structural proteins. Thereby participates in several developmental and physiological processes such as cartilage and bone formation, muscle growth and homeostasis, wound healing and tissue repair. Roles in ECM formation include cleavage of the C-terminal propeptides from procollagens such as procollagen I, II and III or the proteolytic activation of the enzyme lysyl oxidase LOX, necessary to formation of covalent cross-links in collagen and elastic fibers. Additional substrates include matricellular thrombospondin-1/THBS1 whose cleavage leads to cell adhesion disruption and TGF-beta activation. Isoform BMP1-3: Plays an important role in bone repair by acting as a coactivator of BMP7. |
| Protein Name | Bone Morphogenetic Protein 1Bmp-1Mammalian Tolloid ProteinMtldProcollagen C-ProteinasePcp |
| Database Links | Reactome: R-HSA-1474228Reactome: R-HSA-1650814Reactome: R-HSA-2214320Reactome: R-HSA-2243919Reactome: R-HSA-8963896 P13497-3 |
| Cellular Localisation | Golgi ApparatusTrans-Golgi NetworkSecretedExtracellular SpaceExtracellular MatrixCo-Localizes With Postn In The GolgiIsoform Bmp1-3: Secreted |
| Alternative Antibody Names | Anti-Bone Morphogenetic Protein 1 antibodyAnti-Bmp-1 antibodyAnti-Mammalian Tolloid Protein antibodyAnti-Mtld antibodyAnti-Procollagen C-Proteinase antibodyAnti-Pcp antibodyAnti-BMP1 antibodyAnti-PCOLC antibody |
Information sourced from Uniprot.org