Anti-RCN3 antibody (STJA0009366)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human Reticulocalbin 3
General Information
| Short Description | Rabbit polyclonal anti-Reticulocalbin-3 for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | RCN3 |
| Gene ID | 57333 |
| Uniprot ID | RCN3_HUMAN |
| Immunogen | Synthesized peptide derived from human Reticulocalbin 3 |
| Specificity | This antibody detects endogenous levels of Reticulocalbin 3 at Human, Mouse |
Additional Info
| Post Translational Modifications | Degraded by PCSK6 and other endoproteases including FURIN and PCSK5. N-glycosylated. |
| Function | Probable molecular chaperone assisting protein biosynthesis and transport in the endoplasmic reticulum. Required for the proper biosynthesis and transport of pulmonary surfactant-associated protein A/SP-A, pulmonary surfactant-associated protein D/SP-D and the lipid transporter ABCA3. By regulating both the proper expression and the degradation through the endoplasmic reticulum-associated protein degradation pathway of these proteins plays a crucial role in pulmonary surfactant homeostasis. Has an anti-fibrotic activity by negatively regulating the secretion of type I and type III collagens. This calcium-binding protein also transiently associates with immature PCSK6 and regulates its secretion. |
| Protein Name | Reticulocalbin-3Ef-Hand Calcium-Binding Protein Rlp49 |
| Database Links | |
| Cellular Localisation | Endoplasmic Reticulum Lumen |
| Alternative Antibody Names | Anti-Reticulocalbin-3 antibodyAnti-Ef-Hand Calcium-Binding Protein Rlp49 antibodyAnti-RCN3 antibodyAnti-UNQ239 antibodyAnti-PRO272 antibody |
Information sourced from Uniprot.org