Anti-RCE1 antibody (100-200) (STJ11100368)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal RCE1 (100-200) antibody for use in WB, IHC-P, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000IHC-P:1:50-1:200IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | RCE1 |
| Gene ID | 9986 |
| Uniprot ID | FACE2_HUMAN |
| Immunogen Region | 100-200 |
| Immunogen Sequence | SLLTLMGFRLEGIFPAALLP LLLTMILFLGPLMQLSMDCP CDLADGLKVVLAPRSWARCL TDMRWLRNQVIAPLTEELVF RACMLPMLAPCMGLGPAVFT C |
| Specificity | A synthetic peptide corresponding to a sequence within amino acids 100-200 of human RCE1 (NP_005124.1). |
Additional Info
| Tissue Specificity | Ubiquitous. |
| Post Translational Modifications | Ubiquitinated. Undergoes 'Lys-48'- and 'Lys-63'-linked ubiquitination. 'Lys-48' ubiquitination induces its degradation. Deubiquitinated by USP17L2/USP17 that cleaves 'Lys-63'-linked ubiquitin chains. |
| Function | Protease involved in the processing of a variety of prenylated proteins containing the C-terminal CAAX motif, where C is a cysteine modified with an isoprenoid lipid, A is an aliphatic amino acid and X is any C-terminal amino acid. Proteolytically removes the C-terminal three residues of farnesylated and geranylated proteins, leaving the prenylated cysteine as the new C-terminus. Is able to process K-Ras, N-Ras, H-Ras, RAP1B and G-gamma-1. |
| Protein Name | Caax Prenyl Protease 2Farnesylated Proteins-Converting Enzyme 2Face-2Prenyl Protein-Specific Endoprotease 2Rce1 HomologHrce1 |
| Database Links | Reactome: R-HSA-5689880Reactome: R-HSA-9648002 |
| Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Caax Prenyl Protease 2 antibodyAnti-Farnesylated Proteins-Converting Enzyme 2 antibodyAnti-Face-2 antibodyAnti-Prenyl Protein-Specific Endoprotease 2 antibodyAnti-Rce1 Homolog antibodyAnti-Hrce1 antibodyAnti-RCE1 antibodyAnti-FACE2 antibodyAnti-RCE1A antibodyAnti-RCE1B antibody |
Information sourced from Uniprot.org