| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-RCC2 (323-522) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
RCC2 |
| Gene ID: |
55920 |
| Uniprot ID: |
RCC2_HUMAN |
| Immunogen Region: |
323-522 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 323-522 of human RCC2 (NP_001129676.1). |
| Immunogen Sequence: |
QILPVPNVVVRDVACGANHT LVLDSQKRVFSWGFGGYGRL GHAEQKDEMVPRLVKLFDFP GRGASQIYAGYTCSFAVSEV GGLFFWGATNTSRESTMYPK AVQDLCGWRIRSLACGKSSI IVAADESTISWGPSPTFGEL GYGDHKPKSSTAAQEVKTLD GIFSEQVAMGYSHSLVIARD ESETEKEKIKKLPEYNPRTL |
| Function | Multifunctional protein that may affect its functions by regulating the activity of small GTPases, such as RAC1 and RALA. Required for normal progress through the cell cycle, both during interphase and during mitosis. Required for the presence of normal levels of MAD2L1, AURKB and BIRC5 on inner centromeres during mitosis, and for normal attachment of kinetochores to mitotic spindles. Required for normal organization of the microtubule cytoskeleton in interphase cells. Functions as guanine nucleotide exchange factor (GEF) for RALA. Interferes with the activation of RAC1 by guanine nucleotide exchange factors. Prevents accumulation of active, GTP-bound RAC1, and suppresses RAC1-mediated reorganization of the actin cytoskeleton and formation of membrane protrusions. Required for normal cellular responses to contacts with the extracellular matrix of adjacent cells, and for directional cell migration in response to a fibronectin gradient (in vitro). |
| Protein Name | Protein Rcc2Rcc1-Like Protein Td-60Telophase Disk Protein Of 60 Kda |
| Database Links | Reactome: R-HSA-141444Reactome: R-HSA-2467813Reactome: R-HSA-2500257Reactome: R-HSA-5663220Reactome: R-HSA-68877Reactome: R-HSA-9648025 |
| Cellular Localisation | NucleusNucleolusCytoplasmCytoskeletonChromosomeCentromereSpindleMidbodyCell MembranePeripheral Membrane ProteinCytoplasmic SideAppears In The Nucleus At G2Then Concentrates At The Inner Centromere Region Of Chromosomes During ProphaseRedistributes To The Midzone Of The Mitotic Spindle During AnaphaseHereThe Protein Covers The Entire Equatorial Diameter From Cortex To CortexColocalizes With Cytoplasmic Microtubules In Interphase CellsColocalizes With Rac1 At The Cell Membrane |
| Alternative Antibody Names | Anti-Protein Rcc2 antibodyAnti-Rcc1-Like Protein Td-60 antibodyAnti-Telophase Disk Protein Of 60 Kda antibodyAnti-RCC2 antibodyAnti-KIAA1470 antibodyAnti-TD60 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
