Anti-RCC1L antibody (STJA0007651)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human WBSCR16
General Information
| Short Description | Rabbit polyclonal anti-RCC1-like G exchanging factor-like protein for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | RCC1L |
| Gene ID | 81554 |
| Uniprot ID | RCC1L_HUMAN |
| Immunogen | Synthesized peptide derived from human WBSCR16 |
| Specificity | This antibody detects endogenous levels of WBSCR16 at Human, Mouse |
Additional Info
| Function | Guanine nucleotide exchange factor (GEF) for mitochondrial dynamin-related GTPase OPA1. Activates OPA1, by exchanging bound GDP for free GTP, and drives OPA1 and MFN1-dependent mitochondrial fusion. Plays an essential role in mitochondrial ribosome biogenesis. As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mitochondrial ribosomal RNA (16S mt-rRNA), controls 16S mt-rRNA abundance and is required for intra-mitochondrial translation of core subunits of the oxidative phosphorylation system. Isoform 1: Plays an essential role in mitochondrial ribosome biogenesis via its association with GTPases that play a role in the assembly of the large ribosome subunit. Isoform 2: Plays an essential role in mitochondrial ribosome biogenesis via its association with GTPases that play a role in the assembly of the small ribosome subunit. |
| Protein Name | Rcc1-Like G Exchanging Factor-Like ProteinRcc1-Like ProteinWilliams-Beuren Syndrome Chromosomal Region 16 Protein |
| Database Links | |
| Cellular Localisation | Mitochondrion MembraneIsoform 1: Mitochondrion Inner MembraneIsoform 2: Mitochondrion Inner MembraneIsoform 3: Mitochondrion Inner Membrane |
| Alternative Antibody Names | Anti-Rcc1-Like G Exchanging Factor-Like Protein antibodyAnti-Rcc1-Like Protein antibodyAnti-Williams-Beuren Syndrome Chromosomal Region 16 Protein antibodyAnti-RCC1L antibodyAnti-WBSCR16 antibody |
Information sourced from Uniprot.org