Anti-RCAN1/Dscr1 antibody (C-Term) (STJA0041369)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenRCAN1 (C-terminus) synthetic peptide (coupled to carrier protein) corresponds to amino acids in the C-terminus of human RCAN1. This sequence is highly conserved in rat and mouse RCAN1, and this sequence is found in all four isoforms of RCAN1, but is
General Information
| Short Description | Rabbit polyclonal anti-RCAN1/Dscr1 (C-Term) for use in ELISA, WB and ICC in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | ELISA/WB/ICC |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Antigen Affinity Purified |
| Dilution Range | WB 1:1000ICC 1:100 |
| Formulation | PBS + 1 mg/ml BSA, 0.05% NaN3 and 50% glycerol |
| Storage Instruction | Storage at-20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at-20°C. |
Target Information
| Gene Symbol | RCAN1 |
| Gene ID | 1827 |
| Uniprot ID | RCAN1_HUMAN |
| Immunogen | RCAN1 (C-terminus) synthetic peptide (coupled to carrier protein) corresponds to amino acids in the C-terminus of human RCAN1. This sequence is highly conserved in rat and mouse RCAN1, and this sequence is found in all four isoforms of RCAN1, but is |
| Immunogen Region | C-Term |
| Immunogen Sequence | Human |
| Specificity | The antibody detects several isoforms of RCAN1 on SDS-PAGE immunoblots of adult mouse muscle and brain, rat PC12 cells, and human A431 and Jurkat cells. The predominate isoforms detected were the 38 kDa RCAN1L and 31 kDa RCAN1S. |
Additional Info
| Tissue Specificity | Highly expressed heart, brain and skeletal muscle. Also expressed in all other tissues. |
| Post Translational Modifications | Phosphorylation increases its ability to inhibit calcineurin and decreases protein half-life. |
| Function | Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development. |
| Protein Name | Calcipressin-1Adapt78Down Syndrome Critical Region Protein 1Myocyte-Enriched Calcineurin-Interacting Protein 1Mcip1Regulator Of Calcineurin 1 |
| Database Links | |
| Cellular Localisation | |
| Alternative Antibody Names | Anti-Calcipressin-1 antibodyAnti-Adapt78 antibodyAnti-Down Syndrome Critical Region Protein 1 antibodyAnti-Myocyte-Enriched Calcineurin-Interacting Protein 1 antibodyAnti-Mcip1 antibodyAnti-Regulator Of Calcineurin 1 antibodyAnti-RCAN1 antibodyAnti-ADAPT78 antibodyAnti-CSP1 antibodyAnti-DSC1 antibodyAnti-DSCR1 antibody |
Information sourced from Uniprot.org