Anti-RCAN1 antibody (central Region) (STJA0005563)

SKU:
STJA0005563-100

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Host: Rabbit
Applications: WB/ICC
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-RCAN1/Dscr1 (central Region) is suitable for use in Western Blot and Immunocytochemistry research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS + 1 mg/ml BSA, 0.05% NaN3 and 50% glycerol
Purification: Antigen Affinity Purified
Dilution Range: WB 1:1000
IHC
ICC
IP
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: RCAN1
Gene ID: 1827
Uniprot ID: RCAN1_HUMAN
Immunogen Region: central Region
Specificity: The antibody detects several isoforms of RCAN1 on SDS-PAGE immunoblots of mouse C2C12, rat PC12, and human Jurkat cells. The predominate isoform detected is the 38 kDa RCAN1L, but the antibody may also detect RCAN2 and RCAN3.
Immunogen: RCAN1 synthetic peptide (coupled to carrier protein) corresponds to amino acids from the central region of human RCAN1S (isoform 2). This sequence is highly conserved in rat and mouse RCAN1, and this sequence is found in all four isoforms of RCAN1. I
Post Translational Modifications Phosphorylation increases its ability to inhibit calcineurin and decreases protein half-life.
Function Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development.
Protein Name Calcipressin-1
Adapt78
Down Syndrome Critical Region Protein 1
Myocyte-Enriched Calcineurin-Interacting Protein 1
Mcip1
Regulator Of Calcineurin 1
Alternative Antibody Names Anti-Calcipressin-1 antibody
Anti-Adapt78 antibody
Anti-Down Syndrome Critical Region Protein 1 antibody
Anti-Myocyte-Enriched Calcineurin-Interacting Protein 1 antibody
Anti-Mcip1 antibody
Anti-Regulator Of Calcineurin 1 antibody
Anti-RCAN1 antibody
Anti-ADAPT78 antibody
Anti-CSP1 antibody
Anti-DSC1 antibody
Anti-DSCR1 antibody

Information sourced from Uniprot.org

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