| Host: | Rabbit |
| Applications: | WB/ICC |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-RCAN1/Dscr1 (central Region) is suitable for use in Western Blot and Immunocytochemistry research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS + 1 mg/ml BSA, 0.05% NaN3 and 50% glycerol |
| Purification: | Antigen Affinity Purified |
| Dilution Range: | WB 1:1000 ICC 6:00 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | RCAN1 |
| Gene ID: | 1827 |
| Uniprot ID: | RCAN1_HUMAN |
| Immunogen Region: | central Region |
| Specificity: | The antibody detects several isoforms of RCAN1 on SDS-PAGE immunoblots of mouse C2C12, rat PC12, and human Jurkat cells. The predominate isoform detected is the 38 kDa RCAN1L, but the antibody may also detect RCAN2 and RCAN3. |
| Immunogen: | RCAN1 synthetic peptide (coupled to carrier protein) corresponds to amino acids from the central region of human RCAN1S (isoform 2). This sequence is highly conserved in rat and mouse RCAN1, and this sequence is found in all four isoforms of RCAN1. I |
| Post Translational Modifications | Phosphorylation increases its ability to inhibit calcineurin and decreases protein half-life. |
| Function | Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development. |
| Protein Name | Calcipressin-1 Adapt78 Down Syndrome Critical Region Protein 1 Myocyte-Enriched Calcineurin-Interacting Protein 1 Mcip1 Regulator Of Calcineurin 1 |
| Alternative Antibody Names | Anti-Calcipressin-1 antibody Anti-Adapt78 antibody Anti-Down Syndrome Critical Region Protein 1 antibody Anti-Myocyte-Enriched Calcineurin-Interacting Protein 1 antibody Anti-Mcip1 antibody Anti-Regulator Of Calcineurin 1 antibody Anti-RCAN1 antibody Anti-ADAPT78 antibody Anti-CSP1 antibody Anti-DSC1 antibody Anti-DSCR1 antibody |
Information sourced from Uniprot.org