Anti-RBM39 antibody (STJA0007323)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human RBM39
General Information
| Short Description | Rabbit polyclonal anti-RNA-binding protein 39 for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | RBM39 |
| Gene ID | 9584 |
| Uniprot ID | RBM39_HUMAN |
| Immunogen | Synthesized peptide derived from human RBM39 |
| Specificity | This antibody detects endogenous levels of RBM39 at Human, Mouse |
Additional Info
| Post Translational Modifications | Aryl sulfonamide anticancer drugs, such as indisulam (E7070) or E7820, promote ubiquitination and subsequent degradation by the DCX(DCAF15) complex. RBM39 degradation results in splicing defects and death in cancer cell lines. Aryl sulfonamide anticancer drugs change the substrate specificity of DCAF15 by acting as a molecular glue that promotes binding between DCAF15 and weak affinity interactor RBM39. |
| Function | RNA-binding protein that acts as a pre-mRNA splicing factor. Acts by promoting exon inclusion via regulation of exon cassette splicing. Also acts as a transcriptional coactivator for steroid nuclear receptors ESR1/ER-alpha and ESR2/ER-beta, and JUN/AP-1, independently of the pre-mRNA splicing factor activity. |
| Protein Name | Rna-Binding Protein 39Caper AlphaCaperalphaHepatocellular Carcinoma Protein 1Rna-Binding Motif Protein 39Rna-Binding Region-Containing Protein 2Splicing Factor Hcc1 |
| Database Links | Reactome: R-HSA-72163 |
| Cellular Localisation | Nucleus SpeckleConcentrated In Nuclear SpecklesColocalizes With The Core Spliceosomal Snrnp Proteins |
| Alternative Antibody Names | Anti-Rna-Binding Protein 39 antibodyAnti-Caper Alpha antibodyAnti-Caperalpha antibodyAnti-Hepatocellular Carcinoma Protein 1 antibodyAnti-Rna-Binding Motif Protein 39 antibodyAnti-Rna-Binding Region-Containing Protein 2 antibodyAnti-Splicing Factor Hcc1 antibodyAnti-RBM39 antibodyAnti-HCC1 antibodyAnti-RNPC2 antibody |
Information sourced from Uniprot.org