Anti-RBM22 antibody (1-230) (STJ112065)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal RBM22 (1-230) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.09% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | RBM22 |
| Gene ID | 55696 |
| Uniprot ID | RBM22_HUMAN |
| Immunogen Region | 1-230 |
| Immunogen Sequence | MATSLGSNTYNRQNWEDADF PILCQTCLGENPYIRMTKEK YGKECKICARPFTVFRWCPG VRMRFKKTEVCQTCSKLKNV CQTCLLDLEYGLPIQVRDAG LSFKDDMPKSDVNKEYYTQN MEREISNSDGTRPVGMLGKA TSTSDMLLKLARTTPYYKRN RPHICSFWVKGECKRGEECP YRHEKPTDPDDPLADQNIKD RYYGINDPVADKLLKRASTM PRLDPPEDKT |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-230 of human RBM22 (NP_060517.1). |
Additional Info
| Function | Required for pre-mRNA splicing as component of the activated spliceosome. Involved in the first step of pre-mRNA splicing. Binds directly to the internal stem-loop (ISL) domain of the U6 snRNA and to the pre-mRNA intron near the 5' splice site during the activation and catalytic phases of the spliceosome cycle. Involved in both translocations of the nuclear SLU7 to the cytoplasm and the cytosolic calcium-binding protein PDCD6 to the nucleus upon cellular stress responses. |
| Protein Name | Pre-Mrna-Splicing Factor Rbm22Rna-Binding Motif Protein 22Zinc Finger Ccch Domain-Containing Protein 16 |
| Database Links | Reactome: R-HSA-72163 |
| Cellular Localisation | NucleusCytoplasmNearly Exclusively NuclearTranslocated From The Nucleus To The Cytoplasm After Heat Shock Cell TreatmentMay Be Shuttling Between The Nucleus And The Cytosol |
| Alternative Antibody Names | Anti-Pre-Mrna-Splicing Factor Rbm22 antibodyAnti-Rna-Binding Motif Protein 22 antibodyAnti-Zinc Finger Ccch Domain-Containing Protein 16 antibodyAnti-RBM22 antibodyAnti-ZC3H16 antibodyAnti-199G4 antibody |
Information sourced from Uniprot.org