| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | RBM15B |
| Gene ID: | 29890 |
| Uniprot ID: | RB15B_HUMAN |
| Immunogen Region: | 540-720 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 540-720 of human RBM15B (NP_037418.3). |
| Immunogen Sequence: | DRDRTFLEGDWTSPSKSSDR RNSLEGYSRSVRSRSGERWG ADGDRGLPKPWEERRKRRSL SSDRGRTTHSPYEERSRTKG SGQQSERGSDRTPERSRKEN HSSEGTKESSSNSLSNSRHG AEERGHHHHHHEAADSSHGK KARDSERNHRTTEAEPKPLE EPKHETKKLKNLSEYAQTLQ L |
| Tissue Specificity | Ubiquitously expressed. |
| Function | RNA-binding protein that acts as a key regulator of N6-methyladenosine (m6A) methylation of RNAs, thereby regulating different processes, such as alternative splicing of mRNAs and X chromosome inactivation mediated by Xist RNA. Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing. Plays a key role in m6A methylation, possibly by binding target RNAs and recruiting the WMM complex. Involved in random X inactivation mediated by Xist RNA: acts by binding Xist RNA and recruiting the WMM complex, which mediates m6A methylation, leading to target YTHDC1 reader on Xist RNA and promoting transcription repression activity of Xist. Functions in the regulation of alternative or illicit splicing, possibly by regulating m6A methylation. Inhibits pre-mRNA splicing. Also functions as a mRNA export factor by acting as a cofactor for the nuclear export receptor NXF1. |
| Protein Name | Putative Rna-Binding Protein 15b One-Twenty Two Protein 3 Hsott3 Huott3 Rna-Binding Motif Protein 15b |
| Cellular Localisation | Nucleus Nucleoplasm Nucleus Speckle Nucleus Envelope Colocalizes With Bmlf1 In The Nucleus Localized In The Nucleoplasm With A Granular Staining Pattern And Excluded From The Nucleoli |
| Alternative Antibody Names | Anti-Putative Rna-Binding Protein 15b antibody Anti-One-Twenty Two Protein 3 antibody Anti-Hsott3 antibody Anti-Huott3 antibody Anti-Rna-Binding Motif Protein 15b antibody Anti-RBM15B antibody Anti-OTT3 antibody |
Information sourced from Uniprot.org