| Host: |
Rabbit |
| Applications: |
WB/IHC |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Retinoblastoma-binding protein 5 (190-270 aa) is suitable for use in Western Blot and Immunohistochemistry research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000IHC-P 1:50-300 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
RBBP5 |
| Gene ID: |
5929 |
| Uniprot ID: |
RBBP5_HUMAN |
| Immunogen Region: |
190-270 aa |
| Specificity: |
RBQ-3 Polyclonal Antibody detects endogenous levels of RBQ-3 protein. |
| Immunogen: |
Synthesized peptide derived from RBQ-3 at the amino acid range 190-270 |
| Function | In embryonic stem (ES) cells, plays a crucial role in the differentiation potential, particularly along the neural lineage, regulating gene induction and H3 'Lys-4' methylation at key developmental loci, including that mediated by retinoic acid. Does not affect ES cell self-renewal. Component or associated component of some histone methyltransferase complexes which regulates transcription through recruitment of those complexes to gene promoters. As part of the MLL1/MLL complex, involved in mono-, di- and trimethylation at 'Lys-4' of histone H3. Histone H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. In association with ASH2L and WDR5, stimulates the histone methyltransferase activities of KMT2A, KMT2B, KMT2C, KMT2D, SETD1A and SETD1B. |
| Protein Name | Retinoblastoma-Binding Protein 5Rbbp-5Retinoblastoma-Binding Protein Rbq-3 |
| Database Links | Reactome: R-HSA-201722Reactome: R-HSA-3214841Reactome: R-HSA-3769402Reactome: R-HSA-5617472Reactome: R-HSA-8936459Reactome: R-HSA-8951664Reactome: R-HSA-9772755 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Retinoblastoma-Binding Protein 5 antibodyAnti-Rbbp-5 antibodyAnti-Retinoblastoma-Binding Protein Rbq-3 antibodyAnti-RBBP5 antibodyAnti-RBQ3 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
