Anti-RASSF5 antibody (STJA0005761)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthetic peptide corresponding to amino acids from the RA domain of human NORE1
General Information
| Short Description | Rabbit polyclonal anti-RASSF1 for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Antigen Affinity Purified |
| Dilution Range | WB 1:500-1:1000 |
| Formulation | PBS + 0.02% NaN3 |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | RASSF5 |
| Gene ID | 83593 |
| Uniprot ID | RASF5_HUMAN |
| Immunogen | Synthetic peptide corresponding to amino acids from the RA domain of human NORE1 |
| Specificity | Reacts with residues located in the RA domain of human, mouse and rat NORE1 protein. |
Additional Info
| Function | Potential tumor suppressor. Seems to be involved in lymphocyte adhesion by linking RAP1A activation upon T-cell receptor or chemokine stimulation to integrin activation. Isoform 2 stimulates lymphocyte polarization and the patch-like distribution of ITGAL/LFA-1, resulting in an enhanced adhesion to ICAM1. Together with RAP1A may participate in regulation of microtubule growth. The association of isoform 2 with activated RAP1A is required for directional movement of endothelial cells during wound healing. May be involved in regulation of Ras apoptotic function. The RASSF5-STK4/MST1 complex may mediate HRAS and KRAS induced apoptosis. |
| Protein Name | Ras Association Domain-Containing Protein 5New Ras Effector 1Regulator For Cell Adhesion And Polarization Enriched In Lymphoid TissuesRapl |
| Database Links | |
| Cellular Localisation | CytoplasmCytoskeletonIsoform 2 Is Mainly Located In The Perinuclear Region Of Unstimulated Primary T-CellsUpon Stimulation Translocates To The Leading Edge And Colocalizes With Itgal/Lfa-1 In The Peripheral Zone Of The Immunological SynapseIsoform 2 Is Localized To Growing Microtubules In Vascular Endothelial Cells And Is Dissociated From Microtubules By Activated Rap1a |
| Alternative Antibody Names | Anti-Ras Association Domain-Containing Protein 5 antibodyAnti-New Ras Effector 1 antibodyAnti-Regulator For Cell Adhesion And Polarization Enriched In Lymphoid Tissues antibodyAnti-Rapl antibodyAnti-RASSF5 antibodyAnti-NORE1 antibodyAnti-RAPL antibody |
Information sourced from Uniprot.org