Anti-RASSF5 antibody (1-265) (STJ29526)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal RASSF5 (1-265) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | RASSF5 |
| Gene ID | 83593 |
| Uniprot ID | RASF5_HUMAN |
| Immunogen Region | 1-265 |
| Immunogen Sequence | MTVDSSMSSGYCSLDEELED CFFTAKTTFFRNAQSKHLSK NVCKPVEETQRPPTLQEIKQ KIDSYNTREKNCLGMKLSED GTYTGFIKVHLKLRRPVTVP AGIRPQSIYDAIKEVNLAAT TDKRTSFYLPLDAIKQLHIS STTTVSEVIQGLLKKFMVVD NPQKFALFKRIHKDGQVLFQ KLSIADRPLYLRLLAGPDTE VLSFVLKENETGEVEWDAFS IPELQNFLTILEKEEQDKI |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-265 of human RASSF5 (NP_872606.1). |
Additional Info
| Tissue Specificity | Widely expressed. Frequently down-regulated in lung tumor cell lines and primary lung tumors. |
| Function | Potential tumor suppressor. Seems to be involved in lymphocyte adhesion by linking RAP1A activation upon T-cell receptor or chemokine stimulation to integrin activation. Isoform 2 stimulates lymphocyte polarization and the patch-like distribution of ITGAL/LFA-1, resulting in an enhanced adhesion to ICAM1. Together with RAP1A may participate in regulation of microtubule growth. The association of isoform 2 with activated RAP1A is required for directional movement of endothelial cells during wound healing. May be involved in regulation of Ras apoptotic function. The RASSF5-STK4/MST1 complex may mediate HRAS and KRAS induced apoptosis. |
| Protein Name | Ras Association Domain-Containing Protein 5New Ras Effector 1Regulator For Cell Adhesion And Polarization Enriched In Lymphoid TissuesRapl |
| Database Links | |
| Cellular Localisation | CytoplasmCytoskeletonIsoform 2 Is Mainly Located In The Perinuclear Region Of Unstimulated Primary T-CellsUpon Stimulation Translocates To The Leading Edge And Colocalizes With Itgal/Lfa-1 In The Peripheral Zone Of The Immunological SynapseIsoform 2 Is Localized To Growing Microtubules In Vascular Endothelial Cells And Is Dissociated From Microtubules By Activated Rap1a |
| Alternative Antibody Names | Anti-Ras Association Domain-Containing Protein 5 antibodyAnti-New Ras Effector 1 antibodyAnti-Regulator For Cell Adhesion And Polarization Enriched In Lymphoid Tissues antibodyAnti-Rapl antibodyAnti-RASSF5 antibodyAnti-NORE1 antibodyAnti-RAPL antibody |
Information sourced from Uniprot.org