Anti-RASGRP4 antibody (487-537 aa) (STJ198071)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human GRP4 at the amino acid range 487-537
General Information
| Short Description | Rabbit polyclonal anti-RAS guanyl-releasing protein 4 (487-537 aa) for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:1000-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | RASGRP4 |
| Gene ID | 115727 |
| Uniprot ID | GRP4_HUMAN |
| Immunogen | Synthesized peptide derived from the human GRP4 at the amino acid range 487-537 |
| Immunogen Region | 487-537 aa |
| Specificity | This antibody detects endogenous levels of human GRP4 |
Additional Info
| Function | Functions as a cation- and diacylglycerol (DAG)-regulated nucleotide exchange factor activating Ras through the exchange of bound GDP for GTP. In neutrophils, participates in a phospholipase C-activating N-formyl peptide-activated GPCR (G protein-coupled receptor) signaling pathway by promoting Ras-mediated activation of PIK3CG/PI3Kgamma to promote neutrophil functional responses. In CD117(+) dendritic cells and mast cells, participates in an lipopolysaccharide (LPS)-activated signaling pathway that stimulates the production of interferon-gamma and other pro-inflammatory cytokines by natural killer (NK) cells. May function in mast cell differentiation. Does not appear to be required for the development of B-cells, DC-cells, T-cells, or NK-cells. |
| Protein Name | Ras Guanyl-Releasing Protein 4 |
| Database Links | Reactome: R-HSA-2871837Reactome: R-HSA-5673001 |
| Cellular Localisation | CytoplasmCell MembraneRecruited To Membranes Upon Activation By Dag |
| Alternative Antibody Names | Anti-Ras Guanyl-Releasing Protein 4 antibodyAnti-RASGRP4 antibody |
Information sourced from Uniprot.org