Anti-RASGRF2 antibody (1100-1200) {Biotin} (STJ502754)

SKU:
STJ502754-100

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Host: Rabbit
Applications: ELISA/IHC/IP/WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-RASGRF2 (1100-1200) is suitable for use in ELISA, Immunohistochemistry, Immunoprecipitation and Western Blot research applications.
Clonality: Polyclonal
Conjugation: Biotin
Isotype: IgG
Purification: Affinity Purified
Concentration: 0.58 µg/µl
Dilution Range: WB: 1:500
DB: 1:10, 000
ELISA: 1:10, 000
IP: 1:200
IHC: 1:50-1:100
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: RASGRF2
Gene ID: 5924
Uniprot ID: RGRF2_HUMAN
Immunogen Region: 1100-1200
Immunogen: Synthetic peptide taken within amino acid region 1100-1200 on human RASGRF2 protein.
Tissue Specificity Widely expressed with higher expression in brain, followed by heart, lung, pancreas and kidney. Detected in placenta. Expressed in brain and lung (at protein level).
Post Translational Modifications Phosphorylated by CDK5.down-regulates RASGRF2-mediated RAC1 activation. Ubiquitinated upon interaction with Ras. Ubiquitination leads to degradation through the 26S proteasome.
Function Functions as a calcium-regulated nucleotide exchange factor activating both Ras and RAC1 through the exchange of bound GDP for GTP. Preferentially activates HRAS in vivo compared to RRAS based on their different types of prenylation. Functions in synaptic plasticity by contributing to the induction of long term potentiation.
Protein Name Ras-Specific Guanine Nucleotide-Releasing Factor 2
Ras-Grf2
Ras Guanine Nucleotide Exchange Factor 2
Database Links Reactome: R-HSA-193648
Reactome: R-HSA-416482
Reactome: R-HSA-442982
Reactome: R-HSA-5673001
Reactome: R-HSA-8980692
Reactome: R-HSA-9013148
Reactome: R-HSA-9013149
Cellular Localisation Cytoplasm
Cell Membrane
Peripheral Membrane Protein
Endoplasmic Reticulum Membrane
Translocates To Membranes When Activated
Found Both At Cell Periphery And Along The Axon Of Neurons
Alternative Antibody Names Anti-Ras-Specific Guanine Nucleotide-Releasing Factor 2 antibody
Anti-Ras-Grf2 antibody
Anti-Ras Guanine Nucleotide Exchange Factor 2 antibody
Anti-RASGRF2 antibody
Anti-GRF2 antibody

Information sourced from Uniprot.org

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