Anti-RASGRF2 antibody (1100-1200) {Biotin} (STJ502754)

Name: Anti-RASGRF2 antibody (1100-1200) {Biotin} (STJ502754)
SKU: STJ502754-100
Price: 686.55 USD
Availability: InStock

⇓ Datasheet ⇓ SDS

SPECIFICATIONS

ClonalityPolyclonal

HostRabbit

ConjugationBiotin

IsotypeIgG

ImmunogenSynthetic peptide taken within amino acid region 1100-1200 on human RASGRF2 protein.

STJ502754-100

Current Stock:

🚚 Free UK Delivery on orders over £150

Quantity:

Processing The item has been added

Enquire For Bulk Order

✓ 1-Year Performance Guarantee | SDS & Datasheet Included | Expert Tech Support | Covered by St John's Laboratory Guarantee

Short Description	Rabbit polyclonal antibody anti-RASGRF2 (1100-1200) is suitable for use in ELISA, Immunohistochemistry, Immunoprecipitation and Western Blot research applications.
Applications	ELISA/IHC/IP/WB
Host	Rabbit
Reactivity	Human/Mouse/Rat
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Clonality	Polyclonal
Isotype	IgG
Conjugation	Biotin
Concentration	0.58 µg/µl
Purification	Affinity Purified
Dilution Range	WB: 1:500 DB: 1:10, 000 ELISA: 1:10, 000 IP: 1:200 IHC: 1:50-1:100
Formulation	Contains Tris, HCl/Glycine buffer pH 7.4-7.8, 30% Glycerol and 0.5% BSA, along with cryo-protective agents, Hepes, and long-term preservatives (0.02% Sodium Azide).
Storage Instruction	Store at-20°C for long term storage. Avoid freeze-thaw cycles.

Gene Symbol	RASGRF2
Gene ID	5924
Uniprot ID	RGRF2_HUMAN
Immunogen	Synthetic peptide taken within amino acid region 1100-1200 on human RASGRF2 protein.
Immunogen Region	1100-1200

Tissue Specificity	Widely expressed with higher expression in brain, followed by heart, lung, pancreas and kidney. Detected in placenta. Expressed in brain and lung (at protein level).
Post Translational Modifications	Phosphorylated by CDK5.down-regulates RASGRF2-mediated RAC1 activation. Ubiquitinated upon interaction with Ras. Ubiquitination leads to degradation through the 26S proteasome.
Function	Functions as a calcium-regulated nucleotide exchange factor activating both Ras and RAC1 through the exchange of bound GDP for GTP. Preferentially activates HRAS in vivo compared to RRAS based on their different types of prenylation. Functions in synaptic plasticity by contributing to the induction of long term potentiation.
Protein Name	Ras-Specific Guanine Nucleotide-Releasing Factor 2 Ras-Grf2 Ras Guanine Nucleotide Exchange Factor 2
Database Links	Reactome: R-HSA-193648 Reactome: R-HSA-416482 Reactome: R-HSA-442982 Reactome: R-HSA-5673001 Reactome: R-HSA-8980692 Reactome: R-HSA-9013148 Reactome: R-HSA-9013149
Cellular Localisation	Cytoplasm Cell Membrane Peripheral Membrane Protein Endoplasmic Reticulum Membrane Translocates To Membranes When Activated Found Both At Cell Periphery And Along The Axon Of Neurons
Alternative Antibody Names	Anti-Ras-Specific Guanine Nucleotide-Releasing Factor 2 antibody Anti-Ras-Grf2 antibody Anti-Ras Guanine Nucleotide Exchange Factor 2 antibody Anti-RASGRF2 antibody Anti-GRF2 antibody

Information sourced from Uniprot.org