Anti-RASGRF1 antibody (1-190) (STJ29044)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal RASGRF1 (1-190) antibody for use in WB and ELISA in mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | RASGRF1 |
| Gene ID | 5923 |
| Uniprot ID | RGRF1_HUMAN |
| Immunogen Region | 1-190 |
| Immunogen Sequence | MQKGIRLNDGHVASLGLLAR KDGTRKGYLSKRSSDNTKWQ TKWFALLQNLLFYFESDSSS RPSGLYLLEGCVCDRAPSPK PALSAKEPLEKQHYFTVNFS HENQKALELRTEDAKDCDEW VAAIAHASYRTLATEHEALM QKYLHLLQIVETEKTVAKQL RQQIEDGEIEIERLKAEITS LLKDNERIQS |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-190 of human RASGRF1 (NP_001139120.1). |
Additional Info
| Post Translational Modifications | Phosphorylated by PLK2, leading to ubiquitination and degradation by the proteasome. Ubiquitinated and degraded following phosphorylation by PLK2. Phosphorylated by SRC and LCK. Phosphorylation by LCK increases its capacity to stimulate the GDP/GTP exchange on Ras, whereas its phosphorylation by SRC seems not to have an effect on stimulation activity. |
| Function | Promotes the exchange of Ras-bound GDP by GTP. |
| Protein Name | Ras-Specific Guanine Nucleotide-Releasing Factor 1Ras-Grf1Guanine Nucleotide-Releasing ProteinGnrpRas-Specific Nucleotide Exchange Factor Cdc25 |
| Database Links | Reactome: R-HSA-442982Reactome: R-HSA-5673001 |
| Cellular Localisation | |
| Alternative Antibody Names | Anti-Ras-Specific Guanine Nucleotide-Releasing Factor 1 antibodyAnti-Ras-Grf1 antibodyAnti-Guanine Nucleotide-Releasing Protein antibodyAnti-Gnrp antibodyAnti-Ras-Specific Nucleotide Exchange Factor Cdc25 antibodyAnti-RASGRF1 antibodyAnti-CDC25 antibodyAnti-GNRP antibodyAnti-GRF1 antibody |
Information sourced from Uniprot.org