| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-RASA4 (60-290) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
RASA4 |
| Gene ID: |
10156 |
| Uniprot ID: |
RASL2_HUMAN |
| Immunogen Region: |
60-290 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 60-290 of human RASA4 (NP_008920.5). |
| Immunogen Sequence: |
HLPPTFHAVAFYVMDEDALS RDDVIGKVCLTRDTIASHPK GFSGWAHLTEVDPDEEVQGE IHLRLEVWPGARACRLRCSV LEARDLAPKDRNGTSDPFVR VRYKGRTRETSIVKKSCYPR WNETFEFELQEGAMEALCVE AWDWDLVSRNDFLGKVVIDV QRLRVVQQEEGWFRLQPDQS KSRRHDEGNLGSLQLEVRLR DETVLPSSYYQPLVHLLCHE VKLGMQGPGQL |
| Tissue Specificity | Widely expressed. |
| Function | Ca(2+)-dependent Ras GTPase-activating protein, that switches off the Ras-MAPK pathway following a stimulus that elevates intracellular calcium. Functions as an adaptor for Cdc42 and Rac1 during FcR-mediated phagocytosis. |
| Protein Name | Ras Gtpase-Activating Protein 4Calcium-Promoted Ras InactivatorRas P21 Protein Activator 4Rasgap-Activating-Like Protein 2 |
| Database Links | Reactome: R-HSA-5658442 |
| Cellular Localisation | CytoplasmCytosolCell MembranePeripheral Membrane ProteinLocalized To The Cytosol As A Result Of Its Lack Of Phosphoinositide Binding ActivityUpon Agonist-Stimulated Calcium MobilizationUtilizes The C2a And C2b Domains To Associate With The Plasma Membrane |
| Alternative Antibody Names | Anti-Ras Gtpase-Activating Protein 4 antibodyAnti-Calcium-Promoted Ras Inactivator antibodyAnti-Ras P21 Protein Activator 4 antibodyAnti-Rasgap-Activating-Like Protein 2 antibodyAnti-RASA4 antibodyAnti-CAPRI antibodyAnti-GAPL antibodyAnti-KIAA0538 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
