Anti-RARB antibody (350-455) [S7MR] (STJ11102097)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal Retinoic Acid Receptor beta (350-455) antibody for use in WB, IF, ICC and ELISA in human and mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | S7MR |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:1000-1:4000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | RARB |
| Gene ID | 5915 |
| Uniprot ID | RARB_HUMAN |
| Immunogen Region | 350-455 |
| Immunogen Sequence | KLQEPLLEALKIYIRKRRPS KPHMFPKILMKITDLRSISA KGAERVITLKMEIPGSMPPL IQEMLENSEGHEPLTPSSSG NTAEHSPSISPSSVENSGVS QSPLVQ |
| Specificity | A synthetic peptide corresponding to a sequence within amino acids 350-455 of human RAR Beta (NP_000956.2). |
Additional Info
| Tissue Specificity | Expressed in aortic endothelial cells (at protein level). |
| Function | Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence or presence of hormone ligand, acts mainly as an activator of gene expression due to weak binding to corepressors. The RXRA/RARB heterodimer can act as a repressor on the DR1 element and as an activator on the DR5 element. In concert with RARG, required for skeletal growth, matrix homeostasis and growth plate function. |
| Protein Name | Retinoic Acid Receptor BetaRar-BetaHbv-Activated ProteinNuclear Receptor Subfamily 1 Group B Member 2Rar-Epsilon |
| Database Links | Reactome: R-HSA-383280Reactome: R-HSA-5362517Reactome: R-HSA-5617472 |
| Cellular Localisation | NucleusCytoplasmIsoform Beta-1: NucleusIsoform Beta-2: NucleusIsoform Beta-4: Cytoplasm |
| Alternative Antibody Names | Anti-Retinoic Acid Receptor Beta antibodyAnti-Rar-Beta antibodyAnti-Hbv-Activated Protein antibodyAnti-Nuclear Receptor Subfamily 1 Group B Member 2 antibodyAnti-Rar-Epsilon antibodyAnti-RARB antibodyAnti-HAP antibodyAnti-NR1B2 antibody |
Information sourced from Uniprot.org