| Short Description : | Rabbit polyclonal RAPSN (1-353) antibody for use in WB, IHC-P and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/IHC-P/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:2000IHC-P:1:50-1:100ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | RAPSN |
| Gene ID: | 5913 |
| Uniprot ID: | RAPSN_HUMAN |
| Immunogen Region: | 1-353 |
| Immunogen Sequence: | MGQDQTKQQIEKGLQLYQSN QTEKALQVWTKVLEKSSDLM GRFRVLGCLVTAHSEMGRYK EMLKFAVVQIDTARELEDAD FLLESYLNLARSNEKLCEFH KTISYCKTCLGLPGTRAGAQ LGGQVSLSMGNAFLGLSVFQ KALESFEKALRYAHNNDDAM LECRVCCSLGSFYAQVKDYE KALFFPCKAAELVNNYGKGW SLKYRAMSQYHMAVAYRLLG RLGSAMECCEESMKIALQH |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-353 of human RAPSN (NP_116034.2). |
| Post Translational Modifications | Ubiquitinated by the BCR(KLHL8) complex, leading to its degradation. |
| Function | Postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. It may link the receptor to the underlying postsynaptic cytoskeleton, possibly by direct association with actin or spectrin. |
| Protein Name | 43 Kda Receptor-Associated Protein Of The SynapseRapsyn43 Kda Postsynaptic ProteinAcetylcholine Receptor-Associated 43 Kda ProteinRing Finger Protein 205 |
| Database Links | |
| Cellular Localisation | Cell MembranePeripheral Membrane ProteinCytoplasmic SidePostsynaptic Cell MembraneCytoplasmCytoskeletonCytoplasmic Surface Of Postsynaptic Membranes |
| Alternative Antibody Names | Anti-43 Kda Receptor-Associated Protein Of The Synapse antibodyAnti-Rapsyn antibodyAnti-43 Kda Postsynaptic Protein antibodyAnti-Acetylcholine Receptor-Associated 43 Kda Protein antibodyAnti-Ring Finger Protein 205 antibodyAnti-RAPSN antibodyAnti-RNF205 antibody |
Information sourced from Uniprot.org
![Immunofluorescence analysis of PC-12 cells using [KO Validated] PTPN2 Rabbit polyclonal antibody (STJ25225) at dilution of 1:200 (40x lens). Secondary antibody: Cy3 Goat Anti-Rabbit IgG (H+L) at 1:500 dilution. Blue: DAPI for nuclear staining.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/600x533/products/100383/386780/STJ25225_1__40369.1713155922.jpg?c=1 "Immunofluorescence analysis of PC-12 cells using [KO Validated] PTPN2 Rabbit polyclonal antibody (STJ25225) at dilution of 1:200 (40x lens). Secondary antibody: Cy3 Goat Anti-Rabbit IgG (H+L) at 1:500 dilution. Blue: DAPI for nuclear staining.")
