Anti-RAPGEF3 antibody (712-761 aa) (STJ92936)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human RAPGEF3 at the amino acid range 712-761
General Information
| Short Description | Rabbit polyclonal anti-Rap guanine nucleotide exchange factor 3 (712-761 aa) for use in WB and ELISA in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000ELISA 1:40000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | RAPGEF3 |
| Gene ID | 10411 |
| Uniprot ID | RPGF3_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human RAPGEF3 at the amino acid range 712-761 |
| Immunogen Region | 712-761 aa |
| Specificity | Epac Polyclonal Antibody detects endogenous levels of Epac protein. |
Additional Info
| Function | Guanine nucleotide exchange factor (GEF) for RAP1A and RAP2A small GTPases that is activated by binding cAMP. Through simultaneous binding of PDE3B to RAPGEF3 and PIK3R6 is assembled in a signaling complex in which it activates the PI3K gamma complex and which is involved in angiogenesis. Plays a role in the modulation of the cAMP-induced dynamic control of endothelial barrier function through a pathway that is independent on Rho-mediated signaling. Required for the actin rearrangement at cell-cell junctions, such as stress fibers and junctional actin. |
| Protein Name | Rap Guanine Nucleotide Exchange Factor 3Exchange Factor Directly Activated By Camp 1Exchange Protein Directly Activated By Camp 1Epac 1Rap1 Guanine-Nucleotide-Exchange Factor Directly Activated By CampCamp-Regulated Guanine Nucleotide Exchange Factor ICamp-Gefi |
| Database Links | Reactome: R-HSA-354192Reactome: R-HSA-381676Reactome: R-HSA-392517Reactome: R-HSA-422356 |
| Cellular Localisation | Endomembrane System |
| Alternative Antibody Names | Anti-Rap Guanine Nucleotide Exchange Factor 3 antibodyAnti-Exchange Factor Directly Activated By Camp 1 antibodyAnti-Exchange Protein Directly Activated By Camp 1 antibodyAnti-Epac 1 antibodyAnti-Rap1 Guanine-Nucleotide-Exchange Factor Directly Activated By Camp antibodyAnti-Camp-Regulated Guanine Nucleotide Exchange Factor I antibodyAnti-Camp-Gefi antibodyAnti-RAPGEF3 antibodyAnti-CGEF1 antibodyAnti-EPAC antibodyAnti-EPAC1 antibody |
Information sourced from Uniprot.org