Anti-RAPGEF3 antibody (526-541) (STJ500901)

SKU:
STJ500901-100

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Host: Rabbit
Applications: CM/ELISA/ICC/IF/IHC/WB
Reactivity: Horse/Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-RAPGEF3 (526-541) is suitable for use in Confocal Microscopy, ELISA, Immunocytochemistry, Immunofluorescence, Immunohistochemistry and Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Purification: Affinity Purified
Concentration: 0.59 µg/µl
Dilution Range: WB: 1:500
DB: 1:10, 000
ELISA: 1:10, 000
IHC: 1:200
ICC: 1:200
IF: 1:200
CFM: 1:200
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: RAPGEF3
Gene ID: 10411
Uniprot ID: RPGF3_HUMAN
Immunogen Region: 526-541
Specificity: Does not cross react with Epac2.
Immunogen: Synthetic peptide corresponding to amino acids 526-541 of Epac1 protein, peptide was covalently modified. Sequence DHSVLTLQLQLPVTASVR
Tissue Specificity Widely expressed with highest levels in adult kidney, heart, thyroid and brain, and fetal kidney.
Function Guanine nucleotide exchange factor (GEF) for RAP1A and RAP2A small GTPases that is activated by binding cAMP. Through simultaneous binding of PDE3B to RAPGEF3 and PIK3R6 is assembled in a signaling complex in which it activates the PI3K gamma complex and which is involved in angiogenesis. Plays a role in the modulation of the cAMP-induced dynamic control of endothelial barrier function through a pathway that is independent on Rho-mediated signaling. Required for the actin rearrangement at cell-cell junctions, such as stress fibers and junctional actin.
Protein Name Rap Guanine Nucleotide Exchange Factor 3
Exchange Factor Directly Activated By Camp 1
Exchange Protein Directly Activated By Camp 1
Epac 1
Rap1 Guanine-Nucleotide-Exchange Factor Directly Activated By Camp
Camp-Regulated Guanine Nucleotide Exchange Factor I
Camp-Gefi
Database Links Reactome: R-HSA-354192
Reactome: R-HSA-381676
Reactome: R-HSA-392517
Reactome: R-HSA-422356
Cellular Localisation Endomembrane System
Alternative Antibody Names Anti-Rap Guanine Nucleotide Exchange Factor 3 antibody
Anti-Exchange Factor Directly Activated By Camp 1 antibody
Anti-Exchange Protein Directly Activated By Camp 1 antibody
Anti-Epac 1 antibody
Anti-Rap1 Guanine-Nucleotide-Exchange Factor Directly Activated By Camp antibody
Anti-Camp-Regulated Guanine Nucleotide Exchange Factor I antibody
Anti-Camp-Gefi antibody
Anti-RAPGEF3 antibody
Anti-CGEF1 antibody
Anti-EPAC antibody
Anti-EPAC1 antibody

Information sourced from Uniprot.org

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