| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Rat/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Rap1 GTPase-GDP dissociation stimulator 1 (230-310 aa) is suitable for use in Western Blot and ELISA research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000ELISA 1:5000-20000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
RAP1GDS1 |
| Gene ID: |
5910 |
| Uniprot ID: |
GDS1_HUMAN |
| Immunogen Region: |
230-310 aa |
| Specificity: |
GDS1 Polyclonal Antibody detects endogenous levels of protein. |
| Immunogen: |
Synthesized peptide derived from the human protein at the amino acid range 230-310 |
| Function | Acts as a GEF (guanine nucleotide exchange factor) for the Rho family of small GTP-binding proteins (G proteins) that stimulates the dissociation of GDP to enable subsequent binding of GTP. Additionally, appears to chaperone the processing and/or trafficking of small GTPases containing a C-terminal polybasic region independently of GEF activity. Targets include RAP1A/RAP1B, RHOA, RHOB, RHOC, RAC1 and KRAS. Regulates mitochondrial dynamics by controlling RHOT function to promote mitochondrial fission during high calcium conditions. Able to promote the Ca(2+) release from the endoplasmic reticulum via both inositol trisphosphate (Ins3P) and ryanodine sensitive receptors leading to a enhanced mitochondrial Ca(2+) uptake. Isoform 1: Acts as a GEF (guanine nucleotide exchange factor) for unprenylated RHOA. Chaperones the entry and passage of small GTPases through the prenylation pathway. Recognizes the last amino acid in the GTPase C-terminal CAAX motif with a preference for 'Leu' over 'Met', indicating involvement in the geranylgeranylation pathway. Isoform 2: Acts as a GEF (guanine nucleotide exchange factor) for prenylated RHOA. Acts as a GEF for RHOC. Chaperones the downstream trafficking and/or processing of small newly prenylated GTPases. Escorts RAC1 to the nucleus. |
| Protein Name | Rap1 Gtpase-Gdp Dissociation Stimulator 1Exchange Factor SmggdsSmg Gds ProteinSmg P21 Stimulatory Gdp/Gtp Exchange Protein |
| Database Links | Reactome: R-HSA-9013419Reactome: R-HSA-9013425 |
| Cellular Localisation | CytoplasmCytosolEndoplasmic ReticulumMitochondrionNucleusNuclear Import Is Dependent On Complexing With A Gtpase Containing A C-Terminal Polybasic Region |
| Alternative Antibody Names | Anti-Rap1 Gtpase-Gdp Dissociation Stimulator 1 antibodyAnti-Exchange Factor Smggds antibodyAnti-Smg Gds Protein antibodyAnti-Smg P21 Stimulatory Gdp/Gtp Exchange Protein antibodyAnti-RAP1GDS1 antibodyAnti-SMGGDS antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
