Anti-RANK antibody [R07-1T2] (STJA0036737)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthesized peptide derived from human RANK
General Information
| Short Description | Rabbit monoclonal anti-RANK for use in WB in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | R07-1T2 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Affinity Chromatography |
| Dilution Range | WB 1:500-1:1000 |
| Formulation | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | TNFRSF11A |
| Gene ID | 8792 |
| Uniprot ID | TNR11_HUMAN |
| Immunogen | A synthesized peptide derived from human RANK |
Additional Info
| Tissue Specificity | Ubiquitous expression with high levels in skeletal muscle, thymus, liver, colon, small intestine and adrenal gland. |
| Function | Receptor for TNFSF11/RANKL/TRANCE/OPGL.essential for RANKL-mediated osteoclastogenesis. Its interaction with EEIG1 promotes osteoclastogenesis via facilitating the transcription of NFATC1 and activation of PLCG2. Involved in the regulation of interactions between T-cells and dendritic cells. |
| Protein Name | Tumor Necrosis Factor Receptor Superfamily Member 11aOsteoclast Differentiation Factor ReceptorOdfrReceptor Activator Of Nf-KbCd Antigen Cd265 |
| Database Links | Reactome: R-HSA-5668541Reactome: R-HSA-5676594 |
| Cellular Localisation | Isoform 1: Cell MembraneSingle-Pass Type I Membrane ProteinMembrane RaftIsoform Rank-E5a: Cell Membrane |
| Alternative Antibody Names | Anti-Tumor Necrosis Factor Receptor Superfamily Member 11a antibodyAnti-Osteoclast Differentiation Factor Receptor antibodyAnti-Odfr antibodyAnti-Receptor Activator Of Nf-Kb antibodyAnti-Cd Antigen Cd265 antibodyAnti-TNFRSF11A antibodyAnti-RANK antibody |
Information sourced from Uniprot.org