Anti-RANGRF antibody (STJA0009250)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human RANGRF
General Information
| Short Description | Rabbit polyclonal anti-Ran guanine nucleotide release factor for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | RANGRF |
| Gene ID | 29098 |
| Uniprot ID | MOG1_HUMAN |
| Immunogen | Synthesized peptide derived from human RANGRF |
| Specificity | This antibody detects endogenous levels of RANGRF at Human, Mouse |
Additional Info
| Function | May regulate the intracellular trafficking of RAN. Promotes guanine nucleotide release from RAN and inhibits binding of new GTP by preventing the binding of the RAN guanine nucleotide exchange factor RCC1. Regulates the levels of GTP-bound RAN in the nucleus, and thereby plays a role in the regulation of RAN-dependent mitotic spindle dynamics. Enhances the expression of SCN5A at the cell membrane in cardiomyocytes. |
| Protein Name | Ran Guanine Nucleotide Release FactorRangnrfRan-Binding Protein Mog1 |
| Database Links | Reactome: R-HSA-5576892 |
| Cellular Localisation | NucleusCytoplasmPerinuclear RegionCell MembranePeripheral Membrane ProteinCytoplasmic SideMay Shuttle Between The Nucleus And Cytoplasm |
| Alternative Antibody Names | Anti-Ran Guanine Nucleotide Release Factor antibodyAnti-Rangnrf antibodyAnti-Ran-Binding Protein Mog1 antibodyAnti-RANGRF antibodyAnti-MOG1 antibodyAnti-RANGNRF antibodyAnti-HSPC165 antibodyAnti-HSPC236 antibodyAnti-MDS5 antibody |
Information sourced from Uniprot.org