Anti-RANBP16/Exportin 7 antibody (C-Term) (STJ70494)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-RANBP16/Exportin 7 (C-Term) is suitable for use in ELISA, Western Blot and Immunohistochemistry research applications. |
| Applications | Pep-ELISA/WB/IHC |
| Host | Goat |
| Reactivity | Human/Mouse/Dog/Pig/Cow |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:32000.WB: Approx 110kDa band observed in Hela lysates (predicted size of approx. 124kDa according to NP_055839). Recommended concentration: 0.5-1µg/mlIHC: Paraffin embedded Human Testis. Re |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20°C on receipt and minimise freeze-thaw cycles. |
Target Information
| Gene Symbol | XPO7 |
| Gene ID | 23039 |
| Uniprot ID | XPO7_HUMAN |
| Accession Number | NP_001093631.1; NP_055839; NP_001093632.1 |
| Immunogen Region | C-Term |
| Immunogen Sequence | NSTYGVNSNDMMS |
| Specificity | This antibody is expected to recognise all the reported isoforms (NP_001093631.1; NP_055839; NP_001093632.1). |
Additional Info
| Function | Mediates the nuclear export of proteins (cargos) with broad substrate specificity. In the nucleus binds cooperatively to its cargo and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. XPO7 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. |
| Protein Name | Exportin-7Exp7Ran-Binding Protein 16 |
| Cellular Localisation | CytoplasmNucleusShuttles Between The Nucleus And The Cytoplasm |
| Alternative Antibody Names | Anti-Exportin-7 antibodyAnti-Exp7 antibodyAnti-Ran-Binding Protein 16 antibodyAnti-XPO7 antibodyAnti-KIAA0745 antibodyAnti-RANBP16 antibody |
Information sourced from Uniprot.org