Anti-RANBP10 antibody (362-497) (STJ119783)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal RANBP10 (362-497) antibody for use in WB and ELISA in human and mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | RANBP10 |
| Gene ID | 57610 |
| Uniprot ID | RBP10_HUMAN |
| Immunogen Region | 362-497 |
| Immunogen Sequence | YPGSPSLSPRHGPSSSHMHN TGADSPSCSNGVASTKSKQN HSKYPAPSSSSSSSSSSSSS SPSSVNYSESNSTDSTKSQH HSSTSNQETSDSEMEMEAEH YPNGVLGSMSTRIVNGAYKH EDLQTDESSMDDRHPR |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 362-497 of human RANBP10 (NP_065901.1). |
Additional Info
| Tissue Specificity | Broadly expressed, with highest levels in skeletal muscle. |
| Function | May act as an adapter protein to couple membrane receptors to intracellular signaling pathways (Probable). Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but does not affect estrogen-induced transactivation. Acts as a guanine nucleotide exchange factor (GEF) for RAN GTPase. May play an essential role in hemostasis and in maintaining microtubule dynamics with respect to both platelet shape and function. |
| Protein Name | Ran-Binding Protein 10Ranbp10 |
| Database Links | Reactome: R-HSA-8851805 |
| Cellular Localisation | CytoplasmCytosolNucleusPredominantly Cytoplasmic |
| Alternative Antibody Names | Anti-Ran-Binding Protein 10 antibodyAnti-Ranbp10 antibodyAnti-RANBP10 antibodyAnti-KIAA1464 antibody |
Information sourced from Uniprot.org